WSB1

Details:

UniProt Entry: Q9Y6I7
Gene: WSB1
Class: Other E3 Components
Family: Receptor
Protein length: 421
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y6I7
MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL
VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP
EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP
DGSLILVSAS RDKTLRVWDL KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVFL
WNMDKYTMIR KLEGHHHDVV ACDFSPDGAL LATASYDTRV YIWDPHNGDI LMEFGHLFPP
PTPIFAGGAN DRWVRSVSFS HDGLHVASLA DDKMVRFWRI DEDYPVQVAP LSNGLCCAFS
TDGSVLAAGT HDGSVYFWAT PRQVPSLQHL CRMSIRRVMP TQEVQELPIP SKLLEFLSYR
I

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
33	165	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
39	379	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
117	156	Repeat	WD40 repeat	IPR001680	SM00320
136	165	Repeat	WD40 repeat	IPR001680	PS50082
143	157	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
159	199	Repeat	WD40 repeat	IPR001680	SM00320
161	199	Repeat	WD40 repeat	IPR001680	PF00400
166	305	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
166	208	Repeat	WD40 repeat	IPR001680	PS50082
186	200	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
186	200	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
203	242	Repeat	WD40 repeat	IPR001680	SM00320
205	242	Repeat	WD40 repeat	IPR001680	PF00400
210	251	Repeat	WD40 repeat	IPR001680	PS50082
245	284	Repeat	WD40 repeat	IPR001680	SM00320
249	284	Repeat	WD40 repeat	IPR001680	PF00400
252	293	Repeat	WD40 repeat	IPR001680	PS50082
271	285	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
300	339	Repeat	WD40 repeat	IPR001680	SM00320
306	387	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
310	338	Repeat	WD40 repeat	IPR001680	PF00400
314	348	Repeat	WD40 repeat	IPR001680	PS50082
342	379	Repeat	WD40 repeat	IPR001680	SM00320
356	378	Repeat	WD40 repeat	IPR001680	PF00400
358	378	Repeat	WD40 repeat	IPR001680	PS50082
375	419	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
377	421	Domain	SOCS box domain	IPR001496	PS50225
378	421	Domain	SOCS box domain	IPR001496	SM00253
383	417	Domain	SOCS box domain	IPR001496	PF07525
384	420	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0140454	protein aggregate center assembly	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0044314	protein K27-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952039
GO:0005515	protein binding	Molecular Function	IPI	PMID:18093972
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.