TRI17

Details:

UniProt Entry: Q9Y577
Gene: TRIM17
Class: RING
Family: RING5
Protein length: 477
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y577
MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF
PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV
CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE
RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE
ERSTQGPLQM LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR HYWEVGMNIT
GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL STFSALTPVM LMEPPSHMGI
FLDFEAGEVS FYSVSDGSHL HTYSQATFPG PLQPFFCLGA PKSGQMVIST VTMWVKG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	83	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	66	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	65	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	63	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
94	135	Domain	B-box-type zinc finger	IPR000315	SM00336
94	135	Domain	B-box-type zinc finger	IPR000315	PS50119
95	134	Domain	B-box-type zinc finger	IPR000315	PF00643
277	475	Domain	B30.2/SPRY domain	IPR001870	PS50188
288	462	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
290	475	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
293	310	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
294	347	Domain	SPRY-associated	IPR006574	SM00589
296	472	Domain	TRIM17, PRY/SPRY domain	IPR035687	cd15812
333	357	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
348	472	Domain	SPRY domain	IPR003877	SM00449
350	467	Domain	SPRY domain	IPR003877	PF00622
365	378	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
409	433	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
440	458	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0006914	autophagy	Biological Process	IDA	PMID:25127057
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032880	regulation of protein localization	Biological Process	IMP	PMID:25127057
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IPI	PMID:25127057
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9Y5A6	ZSC21	Yes	No	No	No	—	No	Cluster-specific
Q9Y577	TRI17	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y5A6	ZSC21	Yes	No	No	No	—	No	Cluster-specific
Q9Y577	TRI17	Yes	Yes	No	No	—	No	E3-specific