IPP

Details:

UniProt Entry: Q9Y573
Gene: IPP
Class: Other E3 Components
Family: Adaptor
Protein length: 584
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y573
MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP
YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT
EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK
DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI
EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT
ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV
GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV
AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG
RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	584	Family	BTB-kelch protein	IPR017096	PIRSF037037
7	135	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
14	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
17	141	Domain	Actin-binding protein IPP, BTB/POZ domain	IPR030104	cd18256
28	133	Domain	BTB/POZ domain	IPR000210	PF00651
37	134	Domain	BTB/POZ domain	IPR000210	SM00225
37	104	Domain	BTB/POZ domain	IPR000210	PS50097
134	236	Domain	Actin-binding protein IPP, BACK domain	IPR047067	cd18466
139	241	Domain	BTB/Kelch-associated	IPR011705	SM00875
139	240	Domain	BTB/Kelch-associated	IPR011705	PF07707
285	424	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
289	329	Repeat	Kelch repeat type 1	IPR006652	PF01344
289	343	Repeat	Kelch repeat type 1	IPR006652	SM00612
332	377	Repeat	Kelch repeat type 1	IPR006652	PF01344
344	390	Repeat	Kelch repeat type 1	IPR006652	SM00612
361	584	Homologous_superfamily	Galactose oxidase/kelch, beta-propeller	IPR011043	SSF50965
379	423	Repeat	Kelch repeat type 1	IPR006652	PF01344
391	437	Repeat	Kelch repeat type 1	IPR006652	SM00612
426	584	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
426	472	Repeat	Kelch repeat type 1	IPR006652	PF01344
438	485	Repeat	Kelch repeat type 1	IPR006652	SM00612
474	519	Repeat	Kelch repeat type 1	IPR006652	PF01344
486	533	Repeat	Kelch repeat type 1	IPR006652	SM00612
522	572	Repeat	Kelch repeat type 1	IPR006652	PF01344
534	584	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0015629	actin cytoskeleton	Cellular Component	TAS	PMID:10072760
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000120
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183

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