RN114

Details:

UniProt Entry: Q9Y508
Gene: RNF114
Class: RING
Family: RING4
Protein length: 228
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y508
MAAQQRDCGG AAQLAGPAAE ADPLGRFTCP VCLEVYEKPV QVPCGHVFCS ACLQECLKPK
KPVCGVCRSA LAPGVRAVEL ERQIESTETS CHGCRKNFFL SKIRSHVATC SKYQNYIMEG
VKATIKDASL QPRNVPNRYT FPCPYCPEKN FDQEGLVEHC KLFHSTDTKS VVCPICASMP
WGDPNYRSAN FREHIQRRHR FSYDTFVDYD VDEEDMMNQV LQRSIIDQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
17	118	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
27	68	Domain	E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass	IPR042716	cd16540
29	67	Domain	Zinc finger, RING-type	IPR001841	SM00184
29	62	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
29	68	Domain	Zinc finger, RING-type	IPR001841	PS50089
44	53	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
85	117	Domain	Zinc finger C2HC RNF-type	IPR034734	PF18574
91	110	Domain	Zinc finger C2HC RNF-type	IPR034734	PS51803
140	200	Domain	Drought induced 19 protein type, zinc-binding domain	IPR008598	PF05605

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL5218793	ChEMBL	6.62	—	—	COC(=O)C[C@H]1[C@]2(C)C3=C(C)C(c4ccoc4-c4ccc(C(=O)NCCCNC(=O)C[C@@H]5N=C(c6ccc(Cl)cc6)c6c(sc(C)c6C)-n6c(C)nnc65)cc4)C[C@H]3C[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23
E3 Handle	—	PROTACpedia	6.0*	—	—	COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](c4ccoc4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)C23
E3 Handle	—	PROTACDB3	6.0*	—	—	COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](c4ccoc4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23
E3 Binder	CHEMBL5265809	ChEMBL	6.62	—	—	COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](c4ccoc4-c4ccc(C(=O)NCCCNC(=O)C[C@@H]5N=C(c6ccc(Cl)cc6)C6C(C)=C(C)SC6n6c(C)nnc65)cc4)C[C@H]3O[C@@H]2C2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23
E3 Binder	CHEMBL5274261	ChEMBL	6.33	—	—	O=C(CCl)N1N=C(c2ccc(Br)cc2)CC1c1ccc(Br)cc1

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