ARI1

Details:

UniProt Entry: Q9Y4X5
Gene: ARIH1
Class: RBR
Family: RBR
Protein length: 557
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 1wd2, 2m9y, 4kbl, 4kc9, 5tte, 5udh, 7b5l, 7b5m, 7b5n, 7b5s

Protein Sequence ▾

>Q9Y4X5
MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDTL DLGEVELVEP GLGVGGERDG
LLCGETGGGG GSALGPGGGG GGGGGGGGGG PGHEQEEDYR YEVLTAEQIL QHMVECIREV
NEVIQNPATI TRILLSHFNW DKEKLMERYF DGNLEKLFAE CHVINPSKKS RTRQMNTRSS
AQDMPCQICY LNYPNSYFTG LECGHKFCMQ CWSEYLTTKI MEEGMGQTIS CPAHGCDILV
DDNTVMRLIT DSKVKLKYQH LITNSFVECN RLLKWCPAPD CHHVVKVQYP DAKPVRCKCG
RQFCFNCGEN WHDPVKCKWL KKWIKKCDDD SETSNWIAAN TKECPKCHVT IEKDGGCNHM
VCRNQNCKAE FCWVCLGPWE PHGSAWYNCN RYNEDDAKAA RDAQERSRAA LQRYLFYCNR
YMNHMQSLRF EHKLYAQVKQ KMEEMQQHNM SWIEVQFLKK AVDVLCQCRA TLMYTYVFAF
YLKKNNQSII FENNQADLEN ATEVLSGYLE RDISQDSLQD IKQKVQDKYR YCESRRRVLL
QHVHEGYEKD LWEYIED

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
103	472	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
179	270	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
182	393	Domain	TRIAD supradomain	IPR044066	PS51873
186	234	Domain	Zinc finger, RING-type	IPR001841	PS50089
186	234	Domain	Zinc finger, RING-type	IPR001841	SM00184
256	317	Domain	IBR domain	IPR002867	SM00647
257	317	Domain	IBR domain	IPR002867	PF01485
276	347	Domain	Zinc finger, RING-type	IPR001841	SM00184
325	389	Domain	IBR domain	IPR002867	SM00647
338	382	Domain	IBR domain	IPR002867	PF01485
403	524	Domain	Ariadne domain	IPR045840	PF19422

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0039585	PKR/eIFalpha signaling	Biological Process	TAS	Reactome:R-HSA-9833482
GO:0031462	Cul2-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:27565346
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:24076655
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:24076655
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cellular Component	IDA	PMID:24076655
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1169394
GO:0015030	Cajal body	Cellular Component	IEA	GO_REF:0000044
GO:0016604	nuclear body	Cellular Component	IDA	PMID:23059369
GO:0097413	Lewy body	Cellular Component	IDA	PMID:21590270
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:10521492
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	TAS	PMID:10521492
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:11278816

Enzyme–Substrate Interactions ▾


O60573	IF4E2	Yes	Yes	No	No	—	No	E3-specific
Q14190	SIM2	Yes	Yes	No	No	—	No	Cluster-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O60573	IF4E2	Yes	Yes	No	No	—	No	E3-specific
Q14190	SIM2	Yes	Yes	No	No	—	No	Cluster-specific