RN115

Details:

UniProt Entry: Q9Y4L5
Gene: RNF115
Class: RING
Family: RING4
Protein length: 304
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y4L5
MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG
SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR
LPLGRRYRSR GSSRPDRSPA IEGILQHIFA GFFANSAIPG SPHPFSWSGM LHSNPGDYAW
GQTGLDAIVT QLLGQLENTG PPPADKEKIT SLPTVTVTQE QVDMGLECPV CKEDYTVEEE
VRQLPCNHFF HSSCIVPWLE LHDTCPVCRK SLNGEDSTRQ SQSTEASASN RFSNDSQLHD
RWTF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
193	274	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
227	269	Domain	Zinc finger, RING-type	IPR001841	PF13639
228	269	Domain	Zinc finger, RING-type	IPR001841	PS50089
228	268	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Biological Process	IMP	PMID:17684057
GO:0006893	Golgi to plasma membrane transport	Biological Process	IDA	PMID:35343654
GO:0034123	positive regulation of toll-like receptor signaling pathway	Biological Process	IDA	PMID:35343654
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:10196138
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0034122	negative regulation of toll-like receptor signaling pathway	Biological Process	IDA	PMID:35343654
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	IMP	PMID:23418353
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Biological Process	IMP	PMID:23418353
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:16288031
GO:0070534	protein K63-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070936	protein K48-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:35343654
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	PMID:35343654
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:18819927
GO:0005515	protein binding	Molecular Function	IPI	PMID:16925951
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾


Q9Y4L5	RN115	Yes	Yes	No	No	—	No	E3-specific
P36888	FLT3	Yes	Yes	No	No	—	No	Cluster-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y4L5	RN115	Yes	Yes	No	No	—	No	E3-specific
P36888	FLT3	Yes	Yes	No	No	—	No	Cluster-specific