TRAF6

>Q9Y4K3
MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD
NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK
DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI
PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH
QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF
GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS
HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE
ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
36	507	Family	TNF receptor-associated factor TRAF, metazoa	IPR012227	PIRSF015614
50	160	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
67	124	Domain	TNF receptor-associated factor 6, C3HC3D-type RING zinc finger	IPR027139	cd16643
70	108	Domain	Zinc finger, RING-type	IPR001841	SM00184
70	109	Domain	Zinc finger, RING-type	IPR001841	PS50089
85	94	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
151	192	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
157	183	Domain	TNF receptor-associated factor 6, zinc finger 2	IPR041310	PF18048
161	210	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
204	258	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
204	261	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
211	270	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
304	502	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
350	499	Domain	MATH/TRAF domain	IPR002083	PS50144
351	500	Domain	TNF receptor-associated factor 6, MATH domain	IPR037309	cd03776
355	482	Domain	MATH/TRAF domain	IPR002083	SM00061

GO term	Name	Ontology	Evidence	Reference
GO:0000045	autophagosome assembly	Biological Process	IDA	PMID:20713597
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0002637	regulation of immunoglobulin production	Biological Process	IEA	GO_REF:0000107
GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IDA	PMID:21931555
GO:0006955	immune response	Biological Process	IEA	GO_REF:0000107
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:10882101
GO:0009299	mRNA transcription	Biological Process	IDA	PMID:9891032
GO:0009887	animal organ morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process	IEA	GO_REF:0000107
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0032735	positive regulation of interleukin-12 production	Biological Process	IEA	GO_REF:0000107
GO:0032755	positive regulation of interleukin-6 production	Biological Process	IEA	GO_REF:0000107
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:25355951
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:12048232
GO:0038172	interleukin-33-mediated signaling pathway	Biological Process	IDA	PMID:20532808
GO:0038173	interleukin-17A-mediated signaling pathway	Biological Process	IDA	PMID:31376257
GO:0042088	T-helper 1 type immune response	Biological Process	IEA	GO_REF:0000107
GO:0042475	odontogenesis of dentin-containing tooth	Biological Process	IEA	GO_REF:0000107
GO:0042742	defense response to bacterium	Biological Process	IDA	PMID:11460167
GO:0043011	myeloid dendritic cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:11460167
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:25038658
GO:0048468	cell development	Biological Process	IEA	GO_REF:0000107
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:23776175
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:27746020
GO:0071222	cellular response to lipopolysaccharide	Biological Process	IDA	PMID:23776175
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:14703513
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IMP	PMID:18093978
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0001503	ossification	Biological Process	IEA	GO_REF:0000120
GO:0001843	neural tube closure	Biological Process	IEA	GO_REF:0000107
GO:0002223	stimulatory C-type lectin receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-5621481
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0002726	positive regulation of T cell cytokine production	Biological Process	IMP	PMID:15125833
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-166058
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0023035	CD40 signaling pathway	Biological Process	IDA	PMID:8910514
GO:0030316	osteoclast differentiation	Biological Process	IEA	GO_REF:0000107
GO:0031398	positive regulation of protein ubiquitination	Biological Process	NAS	PMID:22412986
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0032147	activation of protein kinase activity	Biological Process	IDA	PMID:17135271
GO:0032481	positive regulation of type I interferon production	Biological Process	IEA	GO_REF:0000107
GO:0032743	positive regulation of interleukin-2 production	Biological Process	IMP	PMID:15125833
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IMP	PMID:12296995
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process	TAS	Reactome:R-HSA-168164
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-937061
GO:0038095	Fc-epsilon receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-2454202
GO:0042102	positive regulation of T cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0043507	positive regulation of JUN kinase activity	Biological Process	NAS	PMID:17135271
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045453	bone resorption	Biological Process	IEA	GO_REF:0000107
GO:0045672	positive regulation of osteoclast differentiation	Biological Process	IDA	PMID:11751921
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IMP	PMID:18093978
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:11751921
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA	PMID:11751921
GO:0046849	bone remodeling	Biological Process	IEA	GO_REF:0000107
GO:0050852	T cell receptor signaling pathway	Biological Process	IMP	PMID:15125833
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:16378096
GO:0070498	interleukin-1-mediated signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0070534	protein K63-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0070555	response to interleukin-1	Biological Process	IDA	PMID:17135271
GO:0071345	cellular response to cytokine stimulus	Biological Process	IMP	PMID:25515214
GO:0097400	interleukin-17-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Biological Process	IEA	GO_REF:0000107
GO:0141124	intracellular signaling cassette	Biological Process	IEA	GO_REF:0000117
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:27746020
GO:1901701	cellular response to oxygen-containing compound	Biological Process	IEA	GO_REF:0000117
GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	Biological Process	IMP	PMID:25515214
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Cellular Component	IC	PMID:19825828
GO:0098978	glutamatergic synapse	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005811	lipid droplet	Cellular Component	ISS	GO_REF:0000024
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:18093978
GO:0005938	cell cortex	Cellular Component	IEA	GO_REF:0000044
GO:0010008	endosome membrane	Cellular Component	TAS	Reactome:R-HSA-177690
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:11751921
GO:0032991	protein-containing complex	Cellular Component	IEA	GO_REF:0000117
GO:0035631	CD40 receptor complex	Cellular Component	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:10094049
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:18758450
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IDA	PMID:23776175
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:15465037
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0042826	histone deacetylase binding	Molecular Function	IPI	PMID:18093978
GO:0043422	protein kinase B binding	Molecular Function	IPI	PMID:19713527
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q99538	LGMN	Yes	Yes	No	No	—	No	E3-specific
P51530	DNA2	Yes	No	No	No	—	No	E3-specific
Q14192	FHL2	Yes	Yes	No	No	—	No	E3-specific
Q9GZQ8	MLP3B	Yes	Yes	No	No	—	No	E3-specific
Q13352	CENPR	Yes	Yes	No	No	—	No	E3-specific
O43561	LAT	Yes	Yes	No	No	—	No	E3-specific
P49116	NR2C2	Yes	Yes	No	No	—	No	E3-specific
Q13568	IRF5	Yes	Yes	No	No	—	No	E3-specific
Q9BQ95	ECSIT	Yes	Yes	No	No	—	No	E3-specific
P42336	PK3CA	Yes	No	No	No	—	No	E3-specific
P49768	PSN1	Yes	Yes	No	No	—	No	E3-specific
Q16584	M3K11	Yes	Yes	No	No	—	No	Cluster-specific
Q08380	LG3BP	Yes	No	No	No	—	No	E3-specific
P42226	STAT6	Yes	No	No	No	—	No	E3-specific
Q9BVN2	RUSC1	Yes	Yes	No	No	19365808	EBI-6260598	E3-specific
P34932	HSP74	Yes	Yes	No	No	—	No	Cluster-specific
P51617	IRAK1	Yes	Yes	Yes	No	12242293, 26752465, 10383454, 11518704	EBI-447766	E3-specific
P26927	HGFL	Yes	No	No	No	—	No	E3-specific