ZN451

Details:

UniProt Entry: Q9Y4E5
Gene: ZNF451
Class: RING
Family: RING10
Protein length: 1061
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 5d2m

Protein Sequence ▾

>Q9Y4E5
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY
TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF
IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF
DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG
HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA
KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL
RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD
QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF
PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL
TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS
SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD
NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL
TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS
DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT
ERKLKQAINY SKSLDMEKGV ENDLSYQNIE EEIVELPDLD YLRTMTHIVF VDFDNWSNFF
GHLPGHLNQG TFIWGFQGGN TNWKPPLNCK IYNYLNRIGC FFLHPRCSKR KDAADFAICM
HAGRLDEQLP KQIPFTILSG DQGFLELENQ FKKTQRPAHI LNPHHLEGDM MCALLNSISD
TTKECDSDDN MGAKNTSIGE EFISTEDVEL EEAIRRSLEE M

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
169	195	Domain	Zinc finger C2H2-type	IPR013087	SM00355
169	200	Domain	Zinc finger C2H2-type	IPR013087	PS50157
171	195	Domain	Zinc finger C2H2-type	IPR013087	PS00028
212	232	Domain	Zinc finger C2H2-type	IPR013087	SM00355
253	277	Domain	Zinc finger C2H2-type	IPR013087	SM00355
255	277	Domain	Zinc finger C2H2-type	IPR013087	PS00028
315	337	Domain	Zinc finger C2H2-type	IPR013087	SM00355
315	337	Domain	Zinc finger C2H2-type	IPR013087	PS50157
317	337	Domain	Zinc finger C2H2-type	IPR013087	PS00028
362	386	Domain	Zinc finger C2H2-type	IPR013087	SM00355
364	386	Domain	Zinc finger C2H2-type	IPR013087	PS00028
498	526	Domain	Zinc finger C2H2-type	IPR013087	PS50157
498	521	Domain	Zinc finger C2H2-type	IPR013087	SM00355
500	521	Domain	Zinc finger C2H2-type	IPR013087	PS00028
531	554	Domain	Zinc finger C2H2-type	IPR013087	SM00355
531	559	Domain	Zinc finger C2H2-type	IPR013087	PS50157
533	554	Domain	Zinc finger C2H2-type	IPR013087	PS00028
606	631	Domain	Zinc finger C2H2-type	IPR013087	SM00355
636	659	Domain	Zinc finger C2H2-type	IPR013087	SM00355
636	664	Domain	Zinc finger C2H2-type	IPR013087	PS50157
638	659	Domain	Zinc finger C2H2-type	IPR013087	PS00028
667	689	Domain	Zinc finger C2H2-type	IPR013087	SM00355
753	776	Domain	Zinc finger C2H2-type	IPR013087	SM00355
789	812	Domain	Zinc finger C2H2-type	IPR013087	SM00355
791	812	Domain	Zinc finger C2H2-type	IPR013087	PS00028
884	1001	Domain	ZNF451, PIN-like domain	IPR041192	PF18479

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016925	protein sumoylation	Biological Process	IBA	GO_REF:0000033
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IMP	PMID:24324267
GO:0060633	negative regulation of transcription initiation by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003714	transcription corepressor activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0043565	sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0061665	SUMO ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0140416	transcription regulator inhibitor activity	Molecular Function	IDA	PMID:24324267

Enzyme–Substrate Interactions ▾

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