DCAF1

Details:

UniProt Entry: Q9Y4B6
Gene: DCAF1
Class: Other E3 Components
Family: Receptor
Protein length: 1507
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y4B6
MTTVVVHVDS KAELTTLLEQ WEKEHGSGQD MVPILTRMSQ LIEKETEEYR KGDPDPFDDR
HPGRADPECM LGHLLRILFK NDDFMNALVN AYVMTSREPP LNTAACRLLL DIMPGLETAV
VFQEKEGIVE NLFKWAREAD QPLRTYSTGL LGGAMENQDI AANYRDENSQ LVAIVLRRLR
ELQLQEVALR QENKRPSPRK LSSEPLLPLD EEAVDMDYGD MAVDVVDGDQ EEASGDMEIS
FHLDSGHKTS SRVNSTTKPE DGGLKKNKSA KQGDRENFRK AKQKLGFSSS DPDRMFVELS
NSSWSEMSPW VIGTNYTLYP MTPAIEQRLI LQYLTPLGEY QELLPIFMQL GSRELMMFYI
DLKQTNDVLL TFEALKHLAS LLLHNKFATE FVAHGGVQKL LEIPRPSMAA TGVSMCLYYL
SYNQDAMERV CMHPHNVLSD VVNYTLWLME CSHASGCCHA TMFFSICFSF RAVLELFDRY
DGLRRLVNLI STLEILNLED QGALLSDDEI FASRQTGKHT CMALRKYFEA HLAIKLEQVK
QSLQRTEGGI LVHPQPPYKA CSYTHEQIVE MMEFLIEYGP AQLYWEPAEV FLKLSCVQLL
LQLISIACNW KTYYARNDTV RFALDVLAIL TVVPKIQLQL AESVDVLDEA GSTVSTVGIS
IILGVAEGEF FIHDAEIQKS ALQIIINCVC GPDNRISSIG KFISGTPRRK LPQNPKSSEH
TLAKMWNVVQ SNNGIKVLLS LLSIKMPITD ADQIRALACK ALVGLSRSST VRQIISKLPL
FSSCQIQQLM KEPVLQDKRS DHVKFCKYAA ELIERVSGKP LLIGTDVSLA RLQKADVVAQ
SRISFPEKEL LLLIRNHLIS KGLGETATVL TKEADLPMTA ASHSSAFTPV TAAASPVSLP
RTPRIANGIA TRLGSHAAVG ASAPSAPTAH PQPRPPQGPL ALPGPSYAGN SPLIGRISFI
RERPSPCNGR KIRVLRQKSD HGAYSQSPAI KKQLDRHLPS PPTLDSIITE YLREQHARCK
NPVATCPPFS LFTPHQCPEP KQRRQAPINF TSRLNRRASF PKYGGVDGGC FDRHLIFSRF
RPISVFREAN EDESGFTCCA FSARERFLML GTCTGQLKLY NVFSGQEEAS YNCHNSAITH
LEPSRDGSLL LTSATWSQPL SALWGMKSVF DMKHSFTEDH YVEFSKHSQD RVIGTKGDIA
HIYDIQTGNK LLTLFNPDLA NNYKRNCATF NPTDDLVLND GVLWDVRSAQ AIHKFDKFNM
NISGVFHPNG LEVIINTEIW DLRTFHLLHT VPALDQCRVV FNHTGTVMYG AMLQADDEDD
LMEERMKSPF GSSFRTFNAT DYKPIATIDV KRNIFDLCTD TKDCYLAVIE NQGSMDALNM
DTVCRLYEVG RQRLAEDEDE EEDQEEEEQE EEDDDEDDDD TDDLDELDTD QLLEAELEED
DNNENAGEDG DNDFSPSDEE LANLLEEGED GEDEDSDADE EVELILGDTD SSDNSDLEDD
IILSLNE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	1494	Family	VPRBP/DCAF1 family	IPR033270	PTHR13129
74	783	Homologous_superfamily	Armadillo-type fold	IPR016024	SSF48371
581	822	Homologous_superfamily	Armadillo-like helical	IPR011989	G3DSA:1.25.10.10
846	878	Domain	LIS1 homology motif	IPR006594	PS50896
846	878	Domain	LIS1 homology motif	IPR006594	SM00667
1080	1401	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
1089	1370	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045732	positive regulation of protein catabolic process	Biological Process	IDA	PMID:11027288
GO:0097510	base-excision repair, AP site formation via deaminated base removal	Biological Process	IDA	PMID:18973764
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:24140421
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0030183	B cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0033151	V(D)J recombination	Biological Process	ISS	GO_REF:0000024
GO:0035212	cell competition in a multicellular organism	Biological Process	IMP	PMID:20644714
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:28242748
GO:0043687	post-translational protein modification	Biological Process	IDA	PMID:24140421
GO:0008180	COP9 signalosome	Cellular Component	IDA	PMID:18850735
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005813	centrosome	Cellular Component	IDA	PMID:28242748
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:16949367
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0016301	kinase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0030331	nuclear estrogen receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0106310	protein serine kinase activity	Molecular Function	IEA	GO_REF:0000116
GO:1990244	histone H2AT120 kinase activity	Molecular Function	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:23063525

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