FBX7

Details:

UniProt Entry: Q9Y3I1
Gene: FBXO7
Class: Other E3 Components
Family: Receptor
Protein length: 522
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y3I1
MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL NYKDPLTGDE
ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN NEQPSLATSS NQTSMQDEQP
SDSFQGQAAQ SGVWNDDSML GPSQNFEAES IQDNAHMAEG TGFYPSEPML CSESVEGQVP
HSLETLYQSA DCSDANDALI VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH
PLCEGSSATL TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD
LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR SVLSLSAVCR
DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH IQRKESPKGR FVMLLPSSTH
TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP
RFDPVGPLPG PNPILPGRGG PNDRFPFRPS RGRPTDGRLS FM

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	95	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
190	317	Domain	PI31 proteasome regulator, N-terminal	IPR021625	PF11566
327	401	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
329	375	Domain	F-box domain	IPR001810	PS50181
335	375	Domain	F-box domain	IPR001810	SM00256
335	378	Domain	F-box domain	IPR001810	PF12937

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030098	lymphocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Biological Process	IDA	PMID:26310625
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IC	PMID:36646384
GO:0045620	negative regulation of lymphocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IC	PMID:36646384
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0000422	autophagy of mitochondrion	Biological Process	IMP	PMID:23933751
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:10531035
GO:0006626	protein targeting to mitochondrion	Biological Process	IMP	PMID:23933751
GO:0010975	regulation of neuron projection development	Biological Process	IMP	PMID:25029497
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031647	regulation of protein stability	Biological Process	IDA	PMID:15145941
GO:0040012	regulation of locomotion	Biological Process	IDA	PMID:26310625
GO:1901526	positive regulation of mitophagy	Biological Process	IEA	GO_REF:0000107
GO:1903599	positive regulation of autophagy of mitochondrion	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IDA	PMID:36646384
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0097409	glial cytoplasmic inclusion	Cellular Component	IDA	PMID:23656991
GO:0097414	classical Lewy body	Cellular Component	IDA	PMID:23656991
GO:0097462	Lewy neurite	Cellular Component	IDA	PMID:23656991
GO:1990037	Lewy body core	Cellular Component	IDA	PMID:23656991
GO:1990038	Lewy body corona	Cellular Component	IDA	PMID:23656991
GO:0000151	ubiquitin ligase complex	Cellular Component	TAS	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:15145941
GO:0032991	protein-containing complex	Cellular Component	IDA	GO_REF:0000054
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:15145941
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:16510124
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:25029497
GO:0046982	protein heterodimerization activity	Molecular Function	IPI	PMID:18495667
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:15145941

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.