ZBT12

Details:

UniProt Entry: Q9Y330
Gene: ZBTB12
Class: RING
Family: RING6
Protein length: 459
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y330
MASGVEVLRF QLPGHEAATL RNMNQLRAEE RFCDVTIVAD SLKFRGHKVI LAACSPFLRD
QFLLNPSSEL QVSLMHSARI VADLLLSCYT GALEFAVRDI VNYLTAASYL QMEHVVEKCR
NALSQFIEPK IGLKEDGVSE ASLVSSISAT KSLLPPARTP KPAPKPPPPP PLPPPLLRPV
KLEFPLDEDL ELKAEEEDED EDEDVSDICI VKVESALEVA HRLKPPGGLG GGLGIGGSVG
GHLGELAQSS VPPSTVAPPQ GVVKACYSLS EDAEGEGLLL IPGGRASVGA TSGLVEAAAV
AMAARGAGGS LGAGGSRGPL PGGFSGGNPL KNIKCTKCPE VFQGVEKLVF HMRAQHFIFM
CPRCGKQFNH SSNLNRHMNV HRGVKSHSCG ICGKCFTQKS TLHDHLNLHS GARPYRCSYC
DVRFAHKPAI RRHLKEQHGK TTAENVLEAS VAEINVLIR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	134	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
9	124	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	125	Domain	BTB/POZ domain	IPR000210	PF00651
33	97	Domain	BTB/POZ domain	IPR000210	PS50097
33	127	Domain	BTB/POZ domain	IPR000210	SM00225
331	387	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
333	356	Domain	Zinc finger C2H2-type	IPR013087	SM00355
359	386	Domain	Zinc finger C2H2-type	IPR013087	PS50157
359	381	Domain	Zinc finger C2H2-type	IPR013087	SM00355
359	381	Domain	Zinc finger C2H2-type	IPR013087	PF00096
361	381	Domain	Zinc finger C2H2-type	IPR013087	PS00028
381	433	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
387	409	Domain	Zinc finger C2H2-type	IPR013087	PF00096
387	414	Domain	Zinc finger C2H2-type	IPR013087	PS50157
387	409	Domain	Zinc finger C2H2-type	IPR013087	SM00355
389	409	Domain	Zinc finger C2H2-type	IPR013087	PS00028
415	438	Domain	Zinc finger C2H2-type	IPR013087	SM00355
415	443	Domain	Zinc finger C2H2-type	IPR013087	PS50157
417	438	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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