ZBT32

Details:

UniProt Entry: Q9Y2Y4
Gene: ZBTB32
Class: RING
Family: RING6
Protein length: 487
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 3m5b

Protein Sequence ▾

>Q9Y2Y4
MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV SQQLGRRGQW
ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL GVQSLEEACW RARGDRAKKP
DPGLKKHQEE PEKPSRNPER ELGDPGEKQK PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA
TQEAQQEQTR SKEKRLQAPV GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ
TSVTPRPSWA EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH EDKAGCPPRP
HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP FSCSLCPQRS RDFSAMTKHL
RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC
CPSSSTT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	117	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
5	111	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	109	Domain	BTB/POZ domain	IPR000210	PF00651
29	87	Domain	BTB/POZ domain	IPR000210	PS50097
29	117	Domain	BTB/POZ domain	IPR000210	SM00225
371	423	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
373	400	Domain	Zinc finger C2H2-type	IPR013087	PS50157
373	395	Domain	Zinc finger C2H2-type	IPR013087	SM00355
373	395	Domain	Zinc finger C2H2-type	IPR013087	PF00096
375	395	Domain	Zinc finger C2H2-type	IPR013087	PS00028
401	423	Domain	Zinc finger C2H2-type	IPR013087	SM00355
413	451	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
428	455	Domain	Zinc finger C2H2-type	IPR013087	PS50157
428	450	Domain	Zinc finger C2H2-type	IPR013087	SM00355
430	450	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005515	protein binding	Molecular Function	IPI	PMID:24722188
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	ISA	GO_REF:0000113
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	ISS	GO_REF:0000024
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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