KLDC2

Details:

UniProt Entry: Q9Y2U9
Gene: KLHDC2
Class: Other E3 Components
Family: Receptor
Protein length: 406
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y2U9
MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD
FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM
LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET
SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA
RMNDLHYLNL DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY
CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH SNEILIFSVQ
PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS NNTSGS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
8	208	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
28	165	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
191	355	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
209	404	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:26138980
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IDA	PMID:16964437
GO:0031462	Cul2-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:26138980
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:25036637

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