KLH20

Details:

UniProt Entry: Q9Y2M5
Gene: KLHL20
Class: Other E3 Components
Family: Adaptor
Protein length: 609
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y2M5
MEGKPMRRCT NIRPGETGMD VTSRCTLGDP NKLPEGVPQP ARMPYISDKH PRQTLEVINL
LRKHRELCDV VLVVGAKKIY AHRVILSACS PYFRAMFTGE LAESRQTEVV IRDIDERAME
LLIDFAYTSQ ITVEEGNVQT LLPAACLLQL AEIQEACCEF LKRQLDPSNC LGIRAFADTH
SCRELLRIAD KFTQHNFQEV MESEEFMLLP ANQLIDIISS DELNVRSEEQ VFNAVMAWVK
YSIQERRPQL PQVLQHVRLP LLSPKFLVGT VGSDPLIKSD EECRDLVDEA KNYLLLPQER
PLMQGPRTRP RKPIRCGEVL FAVGGWCSGD AISSVERYDP QTNEWRMVAS MSKRRCGVGV
SVLDDLLYAV GGHDGSSYLN SVERYDPKTN QWSSDVAPTS TCRTSVGVAV LGGFLYAVGG
QDGVSCLNIV ERYDPKENKW TRVASMSTRR LGVAVAVLGG FLYAVGGSDG TSPLNTVERY
NPQENRWHTI APMGTRRKHL GCAVYQDMIY AVGGRDDTTE LSSAERYNPR TNQWSPVVAM
TSRRSGVGLA VVNGQLMAVG GFDGTTYLKT IEVFDPDANT WRLYGGMNYR RLGGGVGVIK
MTHCESHIW

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
24	606	Family	BTB-kelch protein	IPR017096	PIRSF037037
39	166	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
46	163	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
59	164	Domain	BTB/POZ domain	IPR000210	PF00651
68	165	Domain	BTB/POZ domain	IPR000210	SM00225
68	135	Domain	BTB/POZ domain	IPR000210	PS50097
170	272	Domain	BTB/Kelch-associated	IPR011705	SM00875
170	270	Domain	BTB/Kelch-associated	IPR011705	PF07707
302	605	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
317	352	Repeat	Kelch repeat type 1	IPR006652	PF01344
318	595	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
319	365	Repeat	Kelch repeat type 1	IPR006652	SM00612
354	393	Repeat	Kelch repeat type 1	IPR006652	PF01344
366	413	Repeat	Kelch repeat type 1	IPR006652	SM00612
403	447	Repeat	Kelch repeat type 1	IPR006652	PF01344
414	460	Repeat	Kelch repeat type 1	IPR006652	SM00612
449	494	Repeat	Kelch repeat type 1	IPR006652	PF01344
461	507	Repeat	Kelch repeat type 1	IPR006652	SM00612
496	540	Repeat	Kelch repeat type 1	IPR006652	PF01344
508	554	Repeat	Kelch repeat type 1	IPR006652	SM00612
543	585	Repeat	Kelch repeat type 1	IPR006652	PF01344
555	601	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006895	Golgi to endosome transport	Biological Process	IBA	GO_REF:0000033
GO:0007010	cytoskeleton organization	Biological Process	TAS	PMID:10888605
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035455	response to interferon-alpha	Biological Process	TAS	PMID:20389280
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP	PMID:20389280
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:1990390	protein K33-linked ubiquitination	Biological Process	IDA	PMID:24768539
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005802	trans-Golgi network	Cellular Component	IBA	GO_REF:0000033
GO:0016605	PML body	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0015629	actin cytoskeleton	Cellular Component	TAS	PMID:10888605
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000044
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:24768539
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0019964	type II interferon binding	Molecular Function	IDA	PMID:20389280
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(C)CC1NC(=O)C(CC(=O)O)NC(=O)C2CCCN2C(=O)C(N)CSCc2cccc(c2)CSCC(C(N)=O)NC1=O

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