ZBTB1

Details:

UniProt Entry: Q9Y2K1
Gene: ZBTB1
Class: RING
Family: RING6
Protein length: 713
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y2K1
MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST
AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD
CSSSKCSSSA SSKQNSKMIF GVRMYEDTVA RNGNEANRWC AEPSSTVNTP HNREADEESL
QLGNFPEPLF DVCKKSSVSK LSTPKERVSR RFGRSFTCDS CGFGFSCEKL LDEHVLTCTN
RHLYQNTRSY HRIVDIRDGK DSNIKAEFGE KDSSKTFSAQ TDKYRGDTSQ AADDSASTTG
SRKSSTVESE IASEEKSRAA ERKRIIIKME PEDIPTDELK DFNIIKVTDK DCNESTDNDE
LEDEPEEPFY RYYVEEDVSI KKSGRKTLKP RMSVSADERG GLENMRPPNN SSPVQEDAEN
ASCELCGLTI TEEDLSSHYL AKHIENICAC GKCGQILVKG RQLQEHAQRC GEPQDLTMNG
LGNTEEKMDL EENPDEQSEI RDMFVEMLDD FRDNHYQINS IQKKQLFKHS ACPFRCPNCG
QRFETENLVV EHMSSCLDQD MFKSAIMEEN ERDHRRKHFC NLCGKGFYQR CHLREHYTVH
TKEKQFVCQT CGKQFLRERQ LRLHNDMHKG MARYVCSICD QGNFRKHDHV RHMISHLSAG
ETICQVCFQI FPNNEQLEQH MDVHLYTCGI CGAKFNLRKD MRSHYNAKHL KRT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	146	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
4	114	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	116	Domain	BTB/POZ domain	IPR000210	PF00651
24	121	Domain	BTB/POZ domain	IPR000210	SM00225
24	91	Domain	BTB/POZ domain	IPR000210	PS50097
216	242	Domain	Zinc finger C2H2-type	IPR013087	SM00355
421	443	Domain	Zinc finger C2H2-type	IPR013087	SM00355
534	554	Domain	Zinc finger C2H2-type	IPR013087	SM00355
575	624	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
578	605	Domain	Zinc finger C2H2-type	IPR013087	PS50157
578	600	Domain	Zinc finger C2H2-type	IPR013087	SM00355
580	600	Domain	Zinc finger C2H2-type	IPR013087	PS00028
606	628	Domain	Zinc finger C2H2-type	IPR013087	SM00355
606	633	Domain	Zinc finger C2H2-type	IPR013087	PS50157
608	628	Domain	Zinc finger C2H2-type	IPR013087	PS00028
633	684	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
634	656	Domain	Zinc finger C2H2-type	IPR013087	SM00355
662	684	Domain	Zinc finger C2H2-type	IPR013087	SM00355
664	684	Domain	Zinc finger C2H2-type	IPR013087	PS00028
686	709	Domain	Zinc finger C2H2-type	IPR013087	SM00355
686	713	Domain	Zinc finger C2H2-type	IPR013087	PS50157
688	709	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0030183	B cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0033077	T cell differentiation in thymus	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0002711	positive regulation of T cell mediated immunity	Biological Process	ISS	GO_REF:0000024
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:24657165
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0019985	translesion synthesis	Biological Process	IMP	PMID:24657165
GO:0032825	positive regulation of natural killer cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0034644	cellular response to UV	Biological Process	IMP	PMID:24657165
GO:0042789	mRNA transcription by RNA polymerase II	Biological Process	IDA	PMID:21706167
GO:0045582	positive regulation of T cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0048538	thymus development	Biological Process	ISS	GO_REF:0000024
GO:0051260	protein homooligomerization	Biological Process	IDA	PMID:20797634
GO:2000176	positive regulation of pro-T cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0016604	nuclear body	Cellular Component	IDA	PMID:20797634
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0042803	protein homodimerization activity	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:20211142
GO:0046982	protein heterodimerization activity	Molecular Function	IDA	PMID:22753936
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IDA	PMID:24657165

Enzyme–Substrate Interactions ▾

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