DTX4

Details:

UniProt Entry: Q9Y2E6
Gene: DTX4
Class: RING
Family: RING9
Protein length: 619
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y2E6
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ
HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP
ATSPPMSPCS CPQCVLVMSV KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL
DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL
AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR PPKLVLHPPP
VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK VRHPPDEDCT ICMERLTAPS
GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP
GKMEYHLIPH SLPGHPDCKT IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG
RKVLKLLLVA WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV
LAELAAQGIS EDSTAQEKD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	78	Domain	WWE domain	IPR004170	PS50918
5	90	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
5	615	Family	Deltex family	IPR039398	PTHR12622
5	86	Domain	WWE domain, subgroup	IPR018123	SM00678
8	78	Domain	WWE domain	IPR004170	PF02825
10	78	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
78	168	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
79	165	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
79	155	Domain	WWE domain	IPR004170	PS50918
88	163	Domain	WWE domain, subgroup	IPR018123	SM00678
91	155	Domain	WWE domain	IPR004170	PF02825
389	471	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
409	467	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
409	468	Domain	Zinc finger, RING-type	IPR001841	PS50089
409	467	Domain	Zinc finger, RING-type	IPR001841	SM00184
474	610	Homologous_superfamily	Deltex, C-terminal domain superfamily	IPR039399	G3DSA:3.30.390.130
475	609	Domain	Deltex, C-terminal	IPR039396	PF18102
476	608	Domain	Deltex, C-terminal	IPR039396	cd09633

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045087	innate immune response	Biological Process	IDA	PMID:25636800
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:14703513
GO:0007219	Notch signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0010498	proteasomal protein catabolic process	Biological Process	IDA	PMID:35793002
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0032479	regulation of type I interferon production	Biological Process	TAS	Reactome:R-HSA-3134975
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:27692986
GO:0045824	negative regulation of innate immune response	Biological Process	IDA	PMID:27692986
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:27692986
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IC	PMID:27692986
GO:0005813	centrosome	Cellular Component	IDA	PMID:35793002
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-3249386
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	Reactome:R-HSA-3249386
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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