FBW1A

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
138	177	Domain	D domain of beta-TrCP	IPR021977	SM01028
139	177	Domain	D domain of beta-TrCP	IPR021977	PF12125
173	287	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
189	228	Domain	F-box domain	IPR001810	SM00256
190	228	Domain	F-box domain	IPR001810	PS50181
192	228	Domain	F-box domain	IPR001810	PF12937
286	580	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
290	581	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
292	329	Repeat	WD40 repeat	IPR001680	SM00320
304	329	Repeat	WD40 repeat	IPR001680	PF00400
312	329	Repeat	WD40 repeat	IPR001680	PS50082
332	369	Repeat	WD40 repeat	IPR001680	SM00320
334	369	Repeat	WD40 repeat	IPR001680	PF00400
339	378	Repeat	WD40 repeat	IPR001680	PS50082
356	370	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
356	370	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
372	409	Repeat	WD40 repeat	IPR001680	SM00320
379	418	Repeat	WD40 repeat	IPR001680	PS50082
396	410	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
415	452	Repeat	WD40 repeat	IPR001680	SM00320
419	452	Repeat	WD40 repeat	IPR001680	PF00400
422	461	Repeat	WD40 repeat	IPR001680	PS50082
439	453	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
455	492	Repeat	WD40 repeat	IPR001680	SM00320
458	492	Repeat	WD40 repeat	IPR001680	PF00400
462	501	Repeat	WD40 repeat	IPR001680	PS50082
479	493	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
479	493	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
495	532	Repeat	WD40 repeat	IPR001680	SM00320
496	532	Repeat	WD40 repeat	IPR001680	PF00400
502	533	Repeat	WD40 repeat	IPR001680	PS50082
519	533	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
519	533	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
544	581	Repeat	WD40 repeat	IPR001680	SM00320
547	581	Repeat	WD40 repeat	IPR001680	PF00400
551	590	Repeat	WD40 repeat	IPR001680	PS50082

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0033598	mammary gland epithelial cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0051726	regulation of cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0060444	branching involved in mammary gland duct morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0061136	regulation of proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000117
GO:0042753	positive regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000107
GO:0045862	positive regulation of proteolysis	Biological Process	IEA	GO_REF:0000117
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0060828	regulation of canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0000045	autophagosome assembly	Biological Process	IDA	PMID:28890335
GO:0007040	lysosome organization	Biological Process	IDA	PMID:24448649
GO:0010507	negative regulation of autophagy	Biological Process	IDA	PMID:32561715
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:22017875
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:32561715
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:12048232
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:12087098
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA	PMID:8943371
GO:0050862	positive regulation of T cell receptor signaling pathway	Biological Process	IDA	PMID:38225265
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:38225265
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:22017875
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:11001584
GO:0006470	protein dephosphorylation	Biological Process	ISS	GO_REF:0000024
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:15448698
GO:0007165	signal transduction	Biological Process	TAS	PMID:9990853
GO:0042752	regulation of circadian rhythm	Biological Process	IDA	PMID:15917222
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:15917222
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	TAS	PMID:11001584
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0050860	negative regulation of T cell receptor signaling pathway	Biological Process	IDA	PMID:38225265
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-3361751
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1168642
GO:0008013	beta-catenin binding	Molecular Function	IEA	GO_REF:0000107
GO:0045309	protein phosphorylated amino acid binding	Molecular Function	IEA	GO_REF:0000107
GO:0046983	protein dimerization activity	Molecular Function	IEA	GO_REF:0000002
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:26871637
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IDA	PMID:12820959

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FBW1A

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾