RNF6

Details:

UniProt Entry: Q9Y252
Gene: RNF6
Class: RING
Family: RING9
Protein length: 685
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9Y252
MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL
LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT
GNATRSGQNG NQTWRAVSRT NPNNGEFRFS LEIHVNHENR GFEIHGEDYT DIPLSDSNRD
HTANRQQRST SPVARRTRSQ TSVNFNGSSS NIPRTRLASR GQNPAEGSFS TLGRLRNGIG
GAAGIPRANA SRTNFSSHTN QSGGSELRQR EGQRFGAAHV WENGARSNVT VRNTNQRLEP
IRLRSTSNSR SRSPIQRQSG TVYHNSQRES RPVQQTTRRS VRRRGRTRVF LEQDRERERR
GTAYTPFSNS RLVSRITVEE GEESSRSSTA VRRHPTITLD LQVRRIRPGE NRDRDSIANR
TRSRVGLAEN TVTIESNSGG FRRTISRLER SGIRTYVSTI TVPLRRISEN ELVEPSSVAL
RSILRQIMTG FGELSSLMEA DSESELQRNG QHLPDMHSEL SNLGTDNNRS QHREGSSQDR
QAQGDSTEMH GENETTQPHT RNSDSRGGRQ LRNPNNLVET GTLPILRLAH FFLLNESDDD
DRIRGLTKEQ IDNLSTRHYE HNSIDSELGK ICSVCISDYV TGNKLRQLPC MHEFHIHCID
RWLSENCTCP ICRQPVLGSN IANNG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
594	677	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
631	673	Domain	Zinc finger, RING-type	IPR001841	PF13639
632	673	Domain	Zinc finger, RING-type	IPR001841	PS50089
632	672	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0048675	axon extension	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0030517	negative regulation of axon extension	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IMP	PMID:19345326
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:19345326
GO:0060765	regulation of androgen receptor signaling pathway	Biological Process	IMP	PMID:19345326
GO:0085020	protein K6-linked ubiquitination	Biological Process	IDA	PMID:19345326
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000107
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000107
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:26871637
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IMP	PMID:19345326
GO:0050681	nuclear androgen receptor binding	Molecular Function	IPI	PMID:19345326

Enzyme–Substrate Interactions ▾


P48059	LIMS1	Yes	Yes	No	No	—	No	E3-specific
P55317	FOXA1	Yes	No	No	No	—	No	E3-specific

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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P48059	LIMS1	Yes	Yes	No	No	—	No	E3-specific
P55317	FOXA1	Yes	No	No	No	—	No	E3-specific