PZRN3

Details:

UniProt Entry: Q9UPQ7
Gene: PDZRN3
Class: RING
Family: RING9
Protein length: 1066
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 1uhp, 1wh1

Protein Sequence ▾

>Q9UPQ7
MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG SCPARCRGRL
SAKELNHVLP LKRLILKLDI KCAYATRGCG RVVKLQQLPE HLERCDFAPA RCRHAGCGQV
LLRRDVEAHM RDACDARPVG RCQEGCGLPL THGEQRAGGH CCARALRAHN GALQARLGAL
HKALKKEALR AGKREKSLVA QLAAAQLELQ MTALRYQKKF TEYSARLDSL SRCVAAPPGG
KGEETKSLTL VLHRDSGSLG FNIIGGRPSV DNHDGSSSEG IFVSKIVDSG PAAKEGGLQI
HDRIIEVNGR DLSRATHDQA VEAFKTAKEP IVVQVLRRTP RTKMFTPPSE SQLVDTGTQT
DITFEHIMAL TKMSSPSPPV LDPYLLPEEH PSAHEYYDPN DYIGDIHQEM DREELELEEV
DLYRMNSQDK LGLTVCYRTD DEDDIGIYIS EIDPNSIAAK DGRIREGDRI IQINGIEVQN
REEAVALLTS EENKNFSLLI ARPELQLDEG WMDDDRNDFL DDLHMDMLEE QHHQAMQFTA
SVLQQKKHDE DGGTTDTATI LSNQHEKDSG VGRTDESTRN DESSEQENNG DDATASSNPL
AGQRKLTCSQ DTLGSGDLPF SNESFISADC TDADYLGIPV DECERFRELL ELKCQVKSAT
PYGLYYPSGP LDAGKSDPES VDKELELLNE ELRSIELECL SIVRAHKMQQ LKEQYRESWM
LHNSGFRNYN TSIDVRRHEL SDITELPEKS DKDSSSAYNT GESCRSTPLT LEISPDNSLR
RAAEGISCPS SEGAVGTTEA YGPASKNLLS ITEDPEVGTP TYSPSLKELD PNQPLESKER
RASDGSRSPT PSQKLGSAYL PSYHHSPYKH AHIPAHAQHY QSYMQLIQQK SAVEYAQSQM
SLVSMCKDLS SPTPSEPRME WKVKIRSDGT RYITKRPVRD RLLRERALKI REERSGMTTD
DDAVSEMKMG RYWSKEERKQ HLVKAKEQRR RREFMMQSRL DCLKEQQAAD DRKEMNILEL
SHKKMMKKRN KKIFDNWMTI QELLTHGTKS PDGTRVYNSF LSVTTV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	76	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	53	Domain	Zinc finger, RING-type	IPR001841	PS50089
18	55	Domain	Zinc finger, RING-type	IPR001841	SM00184
33	42	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
77	130	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
101	139	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
239	343	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
245	344	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
249	339	Domain	PDZ domain	IPR001478	PS50106
252	335	Domain	PDZ domain	IPR001478	PF00595
257	339	Domain	PDZ domain	IPR001478	SM00228
413	504	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
414	503	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
419	488	Domain	PDZ domain	IPR001478	PS50106
424	498	Domain	PDZ domain	IPR001478	PF00595
429	504	Domain	PDZ domain	IPR001478	SM00228

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007528	neuromuscular junction development	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000120
GO:0031594	neuromuscular junction	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O15146	MUSK	Yes	Yes	No	No	—	No	E3-specific

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