TRI35

Details:

UniProt Entry: Q9UPQ4
Gene: TRIM35
Class: RING
Family: RING5
Protein length: 493
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9UPQ4
MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC
KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC
CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN MEHALREKAK AFWAMRRSYE AIAKHNQVEA
AWLEGRIRQE FDKLREFLRV EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER
LQMEMKEDDV SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE
SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV FSQGSHAWEV
ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC RTQGVEGDHC VTSDPATSPL
VLAIPRRLRV ELECEEGELS FYDAERHCHL YTFHARFGEV RPYFYLGGAR GAGPPEPLRI
CPLHISVKEE LDG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	99	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
21	61	Domain	Zinc finger, RING-type	IPR001841	PS50089
21	60	Domain	Zinc finger, RING-type	IPR001841	SM00184
36	45	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
96	137	Domain	B-box-type zinc finger	IPR000315	SM00336
96	137	Domain	B-box-type zinc finger	IPR000315	PS50119
99	137	Domain	B-box-type zinc finger	IPR000315	PF00643
284	487	Domain	B30.2/SPRY domain	IPR001870	PS50188
287	483	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
300	483	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
300	317	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
301	352	Domain	SPRY-associated	IPR006574	SM00589
305	351	Domain	SPRY-associated	IPR006574	PF13765
338	362	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
353	484	Domain	SPRY domain	IPR003877	SM00449
356	468	Domain	SPRY domain	IPR003877	PF00622
419	443	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043065	positive regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045930	negative regulation of mitotic cell cycle	Biological Process	IDA	PMID:14662771
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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