TRI33

Details:

UniProt Entry: Q9UPN9
Gene: TRIM33
Class: RING
Family: RING8
Protein length: 1127
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3u5m, 3u5n, 3u5o, 3u5p, 5mr8, 7zdd, 8bd8, 8bd9, 8bdy

Protein Sequence ▾

>Q9UPN9
MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG GRAGAEGGAA
GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA PASAPAPGPS AGPPPGPPAS
LLDTCAVCQQ SLQSRREAEP KLLPCLHSFC LRCLPEPERQ LSVPIPGGSN GDIQQVGVIR
CPVCRQECRQ IDLVDNYFVK DTSEAPSSSD EKSEQVCTSC EDNASAVGFC VECGEWLCKT
CIEAHQRVKF TKDHLIRKKE DVSESVGASG QRPVFCPVHK QEQLKLFCET CDRLTCRDCQ
LLEHKEHRYQ FLEEAFQNQK GAIENLLAKL LEKKNYVHFA ATQVQNRIKE VNETNKRVEQ
EIKVAIFTLI NEINKKGKSL LQQLENVTKE RQMKLLQQQN DITGLSRQVK HVMNFTNWAI
ASGSSTALLY SKRLITFQLR HILKARCDPV PAANGAIRFH CDPTFWAKNV VNLGNLVIES
KPAPGYTPNV VVGQVPPGTN HISKTPGQIN LAQLRLQHMQ QQVYAQKHQQ LQQMRMQQPP
APVPTTTTTT QQHPRQAAPQ MLQQQPPRLI SVQTMQRGNM NCGAFQAHQM RLAQNAARIP
GIPRHSGPQY SMMQPHLQRQ HSNPGHAGPF PVVSVHNTTI NPTSPTTATM ANANRGPTSP
SVTAIELIPS VTNPENLPSL PDIPPIQLED AGSSSLDNLL SRYISGSHLP PQPTSTMNPS
PGPSALSPGS SGLSNSHTPV RPPSTSSTGS RGSCGSSGRT AEKTSLSFKS DQVKVKQEPG
TEDEICSFSG GVKQEKTEDG RRSACMLSSP ESSLTPPLST NLHLESELDA LASLENHVKI
EPADMNESCK QSGLSSLVNG KSPIRSLMHR SARIGGDGNN KDDDPNEDWC AVCQNGGDLL
CCEKCPKVFH LTCHVPTLLS FPSGDWICTF CRDIGKPEVE YDCDNLQHSK KGKTAQGLSP
VDQRKCERLL LYLYCHELSI EFQEPVPASI PNYYKIIKKP MDLSTVKKKL QKKHSQHYQI
PDDFVADVRL IFKNCERFNE MMKVVQVYAD TQEINLKADS EVAQAGKAVA LYFEDKLTEI
YSDRTFAPLP EFEQEEDDGE VTEDSDEDFI QPRRKRLKSD ERPVHIK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
120	207	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
124	185	Domain	Zinc finger, PHD-type	IPR001965	SM00249
125	184	Domain	Zinc finger, RING-type	IPR001841	SM00184
125	185	Domain	Zinc finger, RING-type	IPR001841	PS50089
125	182	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
145	154	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
212	259	Domain	B-box-type zinc finger	IPR000315	PS50119
212	259	Domain	B-box-type zinc finger	IPR000315	SM00336
217	279	Domain	Zinc finger, RING-type	IPR001841	SM00184
271	312	Domain	B-box-type zinc finger	IPR000315	PS50119
271	312	Domain	B-box-type zinc finger	IPR000315	SM00336
274	310	Domain	B-box-type zinc finger	IPR000315	PF00643
319	445	Domain	B-box, C-terminal	IPR003649	SM00502
876	933	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
880	957	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
887	934	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
889	932	Domain	Zinc finger, PHD-type	IPR001965	SM00249
890	932	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
890	931	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
938	1083	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
958	1087	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
959	1082	Domain	Bromodomain	IPR001487	SM00297
966	1049	Domain	Bromodomain	IPR001487	PF00439
974	1046	Domain	Bromodomain	IPR001487	PS50014
990	1006	Domain	Bromodomain	IPR001487	PR00503
1009	1027	Domain	Bromodomain	IPR001487	PR00503
1027	1046	Domain	Bromodomain	IPR001487	PR00503

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	TAS	Reactome:R-HSA-2173795
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA	PMID:19135894
GO:0030514	negative regulation of BMP signaling pathway	Biological Process	IDA	PMID:19135894
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	NAS	PMID:10022127
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0031981	nuclear lumen	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:19135894
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0070410	co-SMAD binding	Molecular Function	IPI	PMID:19135894
GO:0070412	R-SMAD binding	Molecular Function	IPI	PMID:19135894

Enzyme–Substrate Interactions ▾


Q9H6R0	DHX33	Yes	Yes	No	No	—	No	E3-specific

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4451080	ChEMBL	6.5	—	—	COC(=O)c1ccc2nc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)c(NCc3ccccc3)n2c1
E3 Binder	CHEMBL13883	ChEMBL	6.49	V55	—	COc1cc(C=O)ccc1O
E3 Binder	CHEMBL350966	ChEMBL	6.52	—	—	COc1ccc(C=O)c(O)c1
E3 Binder	CHEMBL4452179	ChEMBL	6.26	—	—	COc1ccc(CCNc2c(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)nc3ccccn23)cc1OC
E3 Binder	CHEMBL4448530	ChEMBL	6.27	—	—	COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccc(Br)cn23)cc1
E3 Binder	CHEMBL4446283	ChEMBL	6.19	—	—	COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccccn23)cc1
E3 Binder	CHEMBL4467793	ChEMBL	6.62	—	—	Cc1cccc2c(C=O)c[nH]c12
E3 Binder	CHEMBL543846	ChEMBL	6.55	—	—	Cc1ncc(CO)c(C=O)c1O.Cl
E3 Binder	CHEMBL2229659	ChEMBL	6.51	—	—	Cn1cccc1C=O
E3 Binder	CHEMBL18620	ChEMBL	6.63	MFW	—	O=C1CCCC1
E3 Binder	CHEMBL18737	ChEMBL	6.6	—	—	O=C1CCCCCCC1
E3 Binder	CHEMBL4572394	ChEMBL	6.57	—	—	O=Cc1ccc(N2CCCC2)cc1
E3 Binder	CHEMBL4592980	ChEMBL	6.47	—	—	O=Cc1cccc(-c2ccc(C(=O)O)cc2)c1
E3 Binder	CHEMBL108925	ChEMBL	6.52	—	—	O=Cc1ccccc1O
E3 Binder	CHEMBL4440737	ChEMBL	8.5	—	—	COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccccn23)cc1
E3 Binder	CHEMBL4470967	ChEMBL	7.86	—	—	COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccc(Br)cn23)cc1

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