ING4

Details:

UniProt Entry: Q9UNL4
Gene: ING4
Class: RING
Family: RING1
Protein length: 249
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2k1j, 2m1r, 2pnx, 2vnf, 4afl

Protein Sequence ▾

>Q9UNL4
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD
YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS
VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP
RCSQERKKK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	247	Family	ING family	IPR028651	PTHR10333
6	107	Domain	Inhibitor of growth protein, N-terminal histone-binding	IPR024610	PF12998
6	107	Domain	Inhibitor of growth protein, N-terminal histone-binding	IPR024610	SM01408
166	248	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
189	246	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
196	245	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
198	243	Domain	Zinc finger, PHD-type	IPR001965	SM00249
199	242	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:1902749	regulation of cell cycle G2/M phase transition	Biological Process	IDA	PMID:15251430
GO:0001558	regulation of cell growth	Biological Process	ISS	GO_REF:0000114
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0006473	protein acetylation	Biological Process	IDA	PMID:12750254
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:12750254
GO:0043065	positive regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Biological Process	IDA	PMID:15251430
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:15029197
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0045926	negative regulation of growth	Biological Process	IDA	PMID:12750254
GO:0051726	regulation of cell cycle	Biological Process	IDA	PMID:16387653
GO:0140889	DNA replication-dependent chromatin disassembly	Biological Process	IEA	GO_REF:0000117
GO:2000278	regulation of DNA biosynthetic process	Biological Process	IDA	PMID:16387653
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0045111	intermediate filament cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0000123	histone acetyltransferase complex	Cellular Component	IDA	PMID:16387653
GO:0046972	histone H4K16 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0036408	histone H3K14 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043995	histone H4K5 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043996	histone H4K8 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043997	histone H4K12 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:16387653
GO:0005515	protein binding	Molecular Function	IPI	PMID:12750254
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140002	histone H3K4me3 reader activity	Molecular Function	IDA	PMID:16728974

Enzyme–Substrate Interactions ▾

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