CHIP

>Q9UNE7
MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA
VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA
YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC
QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM
REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV
EDY

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
22	303	Family	E3 ubiquitin-protein ligase CHIP	IPR045200	PTHR46803
24	139	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
25	127	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	SSF48452
26	59	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
60	93	Repeat	Tetratricopeptide repeat	IPR019734	PS50005
60	93	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
94	127	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
94	127	Repeat	Tetratricopeptide repeat	IPR019734	PS50005
142	225	Domain	CHIP, N-terminal tetratricopeptide repeat domain	IPR041312	PF18391
224	303	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
226	300	Domain	U-box domain	IPR003613	PS51698
227	299	Domain	U-box domain	IPR003613	PF04564
227	293	Domain	CHIP , U-box domain	IPR045202	cd16654
230	293	Domain	U-box domain	IPR003613	SM00504

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0000165	MAPK cascade	Biological Process	ISS	GO_REF:0000024
GO:0002931	response to ischemia	Biological Process	ISS	GO_REF:0000024
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:24043303
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Biological Process	IBA	GO_REF:0000033
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0009893	positive regulation of metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010614	negative regulation of cardiac muscle hypertrophy	Biological Process	IEA	GO_REF:0000107
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IMP	PMID:15781469
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process	IEA	GO_REF:0000107
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0031647	regulation of protein stability	Biological Process	IDA	PMID:16809764
GO:0031943	regulation of glucocorticoid metabolic process	Biological Process	IDA	PMID:11146632
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:11146632
GO:0034392	negative regulation of smooth muscle cell apoptotic process	Biological Process	ISS	GO_REF:0000024
GO:0034393	positive regulation of smooth muscle cell apoptotic process	Biological Process	ISS	GO_REF:0000024
GO:0034605	cellular response to heat	Biological Process	ISS	GO_REF:0000024
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0036503	ERAD pathway	Biological Process	IMP	PMID:23990462
GO:0038128	ERBB2 signaling pathway	Biological Process	TAS	Reactome:R-HSA-1227986
GO:0043066	negative regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045862	positive regulation of proteolysis	Biological Process	IBA	GO_REF:0000033
GO:0050821	protein stabilization	Biological Process	IDA	PMID:24043303
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:16307917
GO:0061684	chaperone-mediated autophagy	Biological Process	IEA	GO_REF:0000107
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:16307917
GO:0071218	cellular response to misfolded protein	Biological Process	IBA	GO_REF:0000033
GO:0071456	cellular response to hypoxia	Biological Process	ISS	GO_REF:0000024
GO:0090035	positive regulation of chaperone-mediated protein complex assembly	Biological Process	IDA	PMID:16831871
GO:1901526	positive regulation of mitophagy	Biological Process	ISS	GO_REF:0000024
GO:1904294	positive regulation of ERAD pathway	Biological Process	IMP	PMID:26265139
GO:1904694	negative regulation of vascular associated smooth muscle contraction	Biological Process	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IDA	PMID:23973223
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0030018	Z disc	Cellular Component	IBA	GO_REF:0000033
GO:0005739	mitochondrion	Cellular Component	ISS	GO_REF:0000024
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	PMID:12150907
GO:0042405	nuclear inclusion body	Cellular Component	IDA	PMID:16831871
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:12150907
GO:0031371	ubiquitin conjugating enzyme complex	Cellular Component	TAS	PMID:16307917
GO:0101031	protein folding chaperone complex	Cellular Component	IPI	PMID:16207813
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0001664	G protein-coupled receptor binding	Molecular Function	IPI	PMID:12150907
GO:0005515	protein binding	Molecular Function	IPI	PMID:11146632
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:16280320
GO:0019900	kinase binding	Molecular Function	IPI	PMID:17512523
GO:0030544	Hsp70 protein binding	Molecular Function	IDA	PMID:10330192
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	TAS	PMID:16307917
GO:0030911	TPR domain binding	Molecular Function	IDA	PMID:11146632
GO:0031072	heat shock protein binding	Molecular Function	IPI	PMID:16207813
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000107
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024
GO:0042803	protein homodimerization activity	Molecular Function	ISS	GO_REF:0000024
GO:0046332	SMAD binding	Molecular Function	IPI	PMID:24613385
GO:0048156	tau protein binding	Molecular Function	NAS	PMID:28386764
GO:0051087	protein-folding chaperone binding	Molecular Function	IBA	GO_REF:0000033
GO:0051787	misfolded protein binding	Molecular Function	IDA	PMID:16831871
GO:0051879	Hsp90 protein binding	Molecular Function	IDA	PMID:11146632
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0070412	R-SMAD binding	Molecular Function	IPI	PMID:15781469

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O60762	DPM1	Yes	Yes	No	No	—	No	E3-specific
Q9NPJ1	MKKS	Yes	Yes	No	No	—	No	E3-specific
P60321	NANO2	Yes	Yes	No	No	—	No	E3-specific
Q9Y697	NFS1	Yes	Yes	No	No	—	No	E3-specific
P63241	IF5A1	Yes	Yes	No	No	—	No	E3-specific
P15559	NQO1	Yes	Yes	No	No	—	No	E3-specific
Q8WY41	NANO1	Yes	Yes	No	No	—	No	E3-specific
Q96PH1	NOX5	Yes	Yes	No	No	—	No	E3-specific
P25815	S100P	Yes	Yes	No	No	—	No	E3-specific
Q8TCG1	CIP2A	Yes	Yes	No	No	—	No	E3-specific
P35228	NOS2	Yes	Yes	No	No	—	No	E3-specific
P00558	PGK1	Yes	No	No	No	—	No	E3-specific
Q8IZQ8	MYCD	Yes	Yes	No	No	—	No	E3-specific
Q6ZWH5	NEK10	Yes	No	No	No	—	No	E3-specific
Q12852	M3K12	Yes	Yes	No	No	—	No	E3-specific
Q00613	HSF1	Yes	Yes	No	No	16293251	EBI-7902188	E3-specific
P06213	INSR	Yes	No	No	No	—	No	E3-specific
Q8N6T7	SIR6	Yes	Yes	No	No	25036637	EBI-9380515	E3-specific
P04839	CY24B	Yes	Yes	No	No	—	No	E3-specific
Q03060	CREM	Yes	Yes	No	No	—	No	E3-specific
P17542	TAL1	Yes	Yes	No	No	—	No	E3-specific
P56545	CTBP2	Yes	Yes	No	No	—	No	E3-specific
P07197	NFM	Yes	Yes	No	No	—	No	E3-specific
P80370	DLK1	Yes	Yes	No	No	—	No	E3-specific
P29034	S10A2	Yes	Yes	No	No	—	No	E3-specific
P29475	NOS1	Yes	Yes	No	No	—	No	E3-specific
P10911	MCF2	Yes	Yes	No	No	—	No	E3-specific
P29474	NOS3	Yes	Yes	No	No	—	No	E3-specific
P17612	KAPCA	Yes	Yes	Yes	No	32814053	EBI-25911678	E3-specific
P56817	BACE1	Yes	Yes	No	No	—	No	E3-specific
Q9UPR3	SMG5	Yes	Yes	No	No	—	No	E3-specific
P33402	GCYA2	Yes	Yes	No	No	—	No	E3-specific
P55017	S12A3	Yes	Yes	No	No	—	No	E3-specific
Q16584	M3K11	Yes	Yes	No	No	—	No	Cluster-specific
P07900	HS90A	Yes	Yes	Yes	No	18292230, 19875381, 16275660, 21360678, 16307917	EBI-1783628	E3-specific
Q5S007	LRRK2	Yes	Yes	Yes	No	29513927, 31046837, 24510904, 19196961	EBI-20587199	E3-specific
O15079	SNPH	Yes	No	No	No	—	No	E3-specific
P43694	GATA4	Yes	Yes	No	No	—	No	E3-specific
P11142	HSP7C	Yes	Yes	Yes	No	29568061, 16275660, 25684577, 20618441, 16293251	EBI-7902445	E3-specific
P34932	HSP74	Yes	Yes	No	No	—	No	Cluster-specific
Q13043	STK4	Yes	Yes	No	No	—	No	E3-specific
P35869	AHR	Yes	Yes	No	No	—	No	E3-specific
P22694	KAPCB	Yes	Yes	No	No	—	No	E3-specific
Q86WG3	ATCAY	Yes	Yes	Yes	No	16275660	EBI-1783602	E3-specific
Q15831	STK11	Yes	Yes	No	No	25036637	EBI-9371190	E3-specific