PLAL1

Details:

UniProt Entry: Q9UM63
Gene: PLAGL1
Class: RING
Family: RING6
Protein length: 463
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9UM63
MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK
SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL
TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG
CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP
PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN
HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN
LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ
QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	31	Domain	Zinc finger C2H2-type	IPR013087	PS50157
4	26	Domain	Zinc finger C2H2-type	IPR013087	SM00355
6	26	Domain	Zinc finger C2H2-type	IPR013087	PS00028
12	71	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
32	61	Domain	Zinc finger C2H2-type	IPR013087	PS50157
32	56	Domain	Zinc finger C2H2-type	IPR013087	PF00096
32	56	Domain	Zinc finger C2H2-type	IPR013087	SM00355
34	56	Domain	Zinc finger C2H2-type	IPR013087	PS00028
60	113	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
62	89	Domain	Zinc finger C2H2-type	IPR013087	PS50157
62	84	Domain	Zinc finger C2H2-type	IPR013087	PF00096
62	84	Domain	Zinc finger C2H2-type	IPR013087	SM00355
64	84	Domain	Zinc finger C2H2-type	IPR013087	PS00028
91	118	Domain	Zinc finger C2H2-type	IPR013087	PS50157
91	113	Domain	Zinc finger C2H2-type	IPR013087	SM00355
93	113	Domain	Zinc finger C2H2-type	IPR013087	PS00028
120	142	Domain	Zinc finger C2H2-type	IPR013087	SM00355
120	147	Domain	Zinc finger C2H2-type	IPR013087	PS50157
122	142	Domain	Zinc finger C2H2-type	IPR013087	PS00028
151	202	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
156	178	Domain	Zinc finger C2H2-type	IPR013087	SM00355
156	183	Domain	Zinc finger C2H2-type	IPR013087	PS50157
158	178	Domain	Zinc finger C2H2-type	IPR013087	PS00028
184	212	Domain	Zinc finger C2H2-type	IPR013087	PS50157
184	207	Domain	Zinc finger C2H2-type	IPR013087	SM00355
186	207	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000117
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	TAS	PMID:9671765
GO:0051726	regulation of cell cycle	Biological Process	TAS	PMID:9184226
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.