FZR1

Details:

UniProt Entry: Q9UM11
Gene: FZR1
Class: Other E3 Components
Family: Adaptor
Protein length: 496
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UM11
MDQDYERRLL RQIVIQNENT MPRVTEMRRT LTPASSPVSS PSKHGDRFIP SRAGANWSVN
FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS
TPEKKGLFTY SLSTKRSSPD DGNDVSPYSL SPVSNKSQKL LRSPRKPTRK ISKIPFKVLD
APELQDDFYL NLVDWSSLNV LSVGLGTCVY LWSACTSQVT RLCDLSVEGD SVTSVGWSER
GNLVAVGTHK GFVQIWDAAA GKKLSMLEGH TARVGALAWN AEQLSSGSRD RMILQRDIRT
PPLQSERRLQ GHRQEVCGLK WSTDHQLLAS GGNDNKLLVW NHSSLSPVQQ YTEHLAAVKA
IAWSPHQHGL LASGGGTADR CIRFWNTLTG QPLQCIDTGS QVCNLAWSKH ANELVSTHGY
SQNQILVWKY PSLTQVAKLT GHSYRVLYLA MSPDGEAIVT GAGDETLRFW NVFSKTRSTK
VKWESVSVLN LFTRIR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	481	Family	The WD repeat Cdc20/Fizzy family	IPR033010	PTHR19918
156	472	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
172	474	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
218	257	Repeat	WD40 repeat	IPR001680	SM00320
225	266	Repeat	WD40 repeat	IPR001680	PS50082
226	281	Domain	Anaphase-promoting complex subunit 4, WD40 domain	IPR024977	PF12894
260	297	Repeat	WD40 repeat	IPR001680	SM00320
302	341	Repeat	WD40 repeat	IPR001680	SM00320
307	341	Repeat	WD40 repeat	IPR001680	PF00400
309	350	Repeat	WD40 repeat	IPR001680	PS50082
344	386	Repeat	WD40 repeat	IPR001680	SM00320
347	386	Repeat	WD40 repeat	IPR001680	PF00400
389	429	Repeat	WD40 repeat	IPR001680	SM00320
432	471	Repeat	WD40 repeat	IPR001680	SM00320
436	471	Repeat	WD40 repeat	IPR001680	PF00400
439	480	Repeat	WD40 repeat	IPR001680	PS50082
458	472	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0040020	regulation of meiotic nuclear division	Biological Process	IEA	GO_REF:0000107
GO:0046105	thymidine biosynthetic process	Biological Process	IDA	PMID:14697231
GO:0051603	proteolysis involved in protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0070306	lens fiber cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:1904860	DNA synthesis involved in mitotic DNA replication	Biological Process	IDA	PMID:14697231
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0007095	mitotic G2 DNA damage checkpoint signaling	Biological Process	IDA	PMID:18662541
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0008284	positive regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051445	regulation of meiotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0070979	protein K11-linked ubiquitination	Biological Process	TAS	PMID:21596315
GO:1904668	positive regulation of ubiquitin protein ligase activity	Biological Process	IDA	PMID:11459826
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	Biological Process	IBA	GO_REF:0000033
GO:2000773	negative regulation of cellular senescence	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-174070
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0005680	anaphase-promoting complex	Cellular Component	IBA	GO_REF:0000033
GO:0010997	anaphase-promoting complex binding	Molecular Function	IEA	GO_REF:0000002
GO:0097027	ubiquitin-protein transferase activator activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:10548110
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:14701726
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IBA	GO_REF:0000033

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.