RN112

Details:

UniProt Entry: Q9ULX5
Gene: RNF112
Class: RING
Family: RING9
Protein length: 631
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9ULX5
MPRPALSVTS FCHRLGKRER KQSFMGNSGN SWSHTPFPKL ELGLGPQPMA PRELPTCSIC
LERLRDPISL DCGHDFCIRC FSTHRLPGCE PPCCPECRKI CKQKRGLRSL GEKMKLLPQR
PLPPALQETC PVRAEPLLLV RINASGGLIL RMGAINRCLK HPLARDTPVC LLAVLGEQHS
GKSFLLNHLL QGLPGLESGE GGRPRGGEAS LQGCRWGANG LARGIWMWSH PFLLGKEGKK
VAVFLVDTGD AMSPELSRET RIKLCALTTM LSSYQILSTS QELKDTDLDY LEMFVHVAEV
MGKHYGMVPI QHLDLLVRDS SHPNKAGQGH VGNIFQRLSG RYPKVQELLQ GKRARCCLLP
APGRRRMNQG HASPGDTDDD FRHLLGAYVS DVLSAAPQHA KSRCQGYWNE GRAVARGDRR
LLTGQQLAQE IKNLSGWMGR TGPGFTSPDE MAAQLHDLRK VEAAKREFEE YVRQQDVATK
RIFSALRVLP DTMRNLLSTQ KDAILARHGV ALLCKGRDQT LEALEAELQA TAKAFMDSYT
MRFCGHLAAV GGAVGAGLMG LAGGVVGAGM AAAALAAEAG MVAAGAAVGA TGAAVVGGGV
GAGLAATVGC MEKEEDERLL EGDREPLLQE E

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
47	120	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
57	97	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
57	98	Domain	Zinc finger, RING-type	IPR001841	PS50089
57	97	Domain	Zinc finger, RING-type	IPR001841	SM00184
133	416	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
137	323	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
163	329	Domain	Guanylate-binding protein, N-terminal	IPR015894	PF02263
166	397	Domain	GB1/RHD3-type guanine nucleotide-binding (G) domain	IPR030386	PS51715

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045666	positive regulation of neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045687	positive regulation of glial cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0070315	G1 to G0 transition involved in cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0007029	endoplasmic reticulum organization	Biological Process	IBA	GO_REF:0000033
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030182	neuron differentiation	Biological Process	IEA	GO_REF:0000120
GO:0033194	response to hydroperoxide	Biological Process	ISS	GO_REF:0000024
GO:0051260	protein homooligomerization	Biological Process	IBA	GO_REF:0000033
GO:0051726	regulation of cell cycle	Biological Process	IDA	PMID:28684796
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:1990403	embryonic brain development	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0005768	endosome	Cellular Component	ISS	GO_REF:0000024
GO:0008021	synaptic vesicle	Cellular Component	ISS	GO_REF:0000024
GO:0014069	postsynaptic density	Cellular Component	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016604	nuclear body	Cellular Component	ISS	GO_REF:0000024
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043005	neuron projection	Cellular Component	IEA	GO_REF:0000044
GO:0043204	perikaryon	Cellular Component	IEA	GO_REF:0000044
GO:0044297	cell body	Cellular Component	ISS	GO_REF:0000024
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003924	GTPase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0005525	GTP binding	Molecular Function	ISS	GO_REF:0000024
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

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