CBLC

Details:

UniProt Entry: Q9ULV8
Gene: CBLC
Class: RING
Family: RING9
Protein length: 474
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3op0, 3vrn, 3vro, 3vrp, 3vrq, 3vrr

Protein Sequence ▾

>Q9ULV8
MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ
LAKLAIIFSH MHAELHALFP GGKYCGHMYQ LTKAPAHTFW RESCGARCVL PWAEFESLLG
TCHPVEPGCT ALALRTTIDL TCSGHVSIFE FDVFTRLFQP WPTLLKNWQL LAVNHPGYMA
FLTYDEVQER LQACRDKPGS YIFRPSCTRL GQWAIGYVSS DGSILQTIPA NKPLSQVLLE
GQKDGFYLYP DGKTHNPDLT ELGQAEPQQR IHVSEEQLQL YWAMDSTFEL CKICAESNKD
VKIEPCGHLL CSCCLAAWQH SDSQTCPFCR CEIKGWEAVS IYQFHGQATA EDSGNSSDQE
GRELELGQVP LSAPPLPPRP DLPPRKPRNA QPKVRLLKGN SPPAALGPQD PAPA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	321	Domain	Adaptor protein Cbl, PTB domain	IPR024159	PS51506
10	147	Homologous_superfamily	Adaptor protein Cbl, N-terminal domain superfamily	IPR036537	SSF47668
12	145	Homologous_superfamily	Adaptor protein Cbl, N-terminal domain superfamily	IPR036537	G3DSA:1.20.930.20
14	145	Domain	Adaptor protein Cbl, N-terminal helical	IPR003153	PF02262
14	450	Family	Adaptor protein Cbl	IPR024162	PTHR23007
148	233	Homologous_superfamily	EF-hand domain pair	IPR011992	SSF47473
149	232	Domain	Adaptor protein Cbl, EF hand-like	IPR014741	PF02761
226	322	Domain	Adaptor protein Cbl, SH2-like domain	IPR014742	cd09920
234	319	Domain	Adaptor protein Cbl, SH2-like domain	IPR014742	PF02762
234	320	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
235	321	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
322	405	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
351	389	Domain	Zinc finger, RING-type	IPR001841	SM00184
351	390	Domain	Zinc finger, RING-type	IPR001841	PS50089
366	375	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007166	cell surface receptor signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0023051	regulation of signaling	Biological Process	IEA	GO_REF:0000002
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0050821	protein stabilization	Biological Process	IEA	GO_REF:0000107
GO:1990790	response to glial cell derived neurotrophic factor	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:14661060
GO:0007165	signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0043409	negative regulation of MAPK cascade	Biological Process	IDA	PMID:10362357
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0045121	membrane raft	Cellular Component	IBA	GO_REF:0000033
GO:0001784	phosphotyrosine residue binding	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005509	calcium ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005154	epidermal growth factor receptor binding	Molecular Function	IDA	PMID:10362357
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0017124	SH3 domain binding	Molecular Function	IEA	GO_REF:0000043
GO:0030971	receptor tyrosine kinase binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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