ZNRF3

Details:

UniProt Entry: Q9ULT6
Gene: ZNRF3
Class: RING
Family: RING9
Protein length: 936
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4ufs

Protein Sequence ▾

>Q9ULT6
MRPRSGGRPG ATGRRRRRLR RRPRGLRCSR LPPPPPLPLL LGLLLAAAGP GAARAKETAF
VEVVLFESSP SGDYTTYTTG LTGRFSRAGA TLSAEGEIVQ MHPLGLCNNN DEEDLYEYGW
VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE NPEAIDQLNQ GSEDPLKRPV
VYVKGADAIK LMNIVNKQKV ARARIQHRPP RQPTEYFDMG IFLAFFVVVS LVCLILLVKI
KLKQRRSQNS MNRLAVQALE KMETRKFNSK SKGRREGSCG ALDTLSSSST SDCAICLEKY
IDGEELRVIP CTHRFHRKCV DPWLLQHHTC PHCRHNIIEQ KGNPSAVCVE TSNLSRGRQQ
RVTLPVHYPG RVHRTNAIPA YPTRTSMDSH GNPVTLLTMD RHGEQSLYSP QTPAYIRSYP
PLHLDHSLAA HRCGLEHRAY SPAHPFRRPK LSGRSFSKAA CFSQYETMYQ HYYFQGLSYP
EQEGQSPPSL APRGPARAFP PSGSGSLLFP TVVHVAPPSH LESGSTSSFS CYHGHRSVCS
GYLADCPGSD SSSSSSSGQC HCSSSDSVVD CTEVSNQGVY GSCSTFRSSL SSDYDPFIYR
SRSPCRASEA GGSGSSGRGP ALCFEGSPPP EELPAVHSHG AGRGEPWPGP ASPSGDQVST
CSLEMNYSSN SSLEHRGPNS STSEVGLEAS PGAAPDLRRT WKGGHELPSC ACCCEPQPSP
AGPSAGAAGS STLFLGPHLY EGSGPAGGEP QSGSSQGLYG LHPDHLPRTD GVKYEGLPCC
FYEEKQVARG GGGGSGCYTE DYSVSVQYTL TEEPPPGCYP GARDLSQRIP IIPEDVDCDL
GLPSDCQGTH SLGSWGGTRG PDTPRPHRGL GATREEERAL CCQARALLRP GCPPEEAGAV
RANFPSALQD TQESSTTATE AAGPRSHSAD SSSPGA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
101	208	Domain	ZNRF-3, ectodomain	IPR040700	PF18212
239	339	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
292	334	Domain	Zinc finger, RING-type	IPR001841	PF13639
292	336	Domain	E3 ubiquitin-protein ligase ZNRF3, Zinc finger, RING-type	IPR045903	cd16799
293	334	Domain	Zinc finger, RING-type	IPR001841	PS50089
293	333	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030178	negative regulation of Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0038018	Wnt receptor catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0060173	limb development	Biological Process	ISS	GO_REF:0000024
GO:0060828	regulation of canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0072089	stem cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:2000050	regulation of non-canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:2000051	negative regulation of non-canonical Wnt signaling pathway	Biological Process	IMP	PMID:22575959
GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway	Biological Process	IEA	GO_REF:0000107
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:22575959
GO:0005109	frizzled binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:22575959
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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