KCNS2

Details:

UniProt Entry: Q9ULS6
Gene: KCNS2
Class: Other E3 Components
Family: Adaptor
Protein length: 477
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9ULS6
MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD
DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS
YSYHGRKVEP EQEKWDEQSD QESTTSSFDE ILAFYNDASK FDGQPLGNFR RQLWLALDNP
GYSVLSRVFS ILSILVVMGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF
ELVARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT
IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ
KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMSRSSPSEL SLNDSLR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	130	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
17	129	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
17	126	Domain	BTB/POZ domain	IPR000210	SM00225
19	118	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
22	34	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
37	53	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
60	73	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
68	78	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
84	99	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
107	119	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
160	311	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
187	420	Domain	Ion transport domain	IPR005821	PF00520
193	205	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
304	312	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
328	342	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
397	415	Family	Potassium channel, voltage dependent, Kv9	IPR003971	PR01494
398	409	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	ISS	GO_REF:0000024
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IBA	GO_REF:0000033
GO:1901379	regulation of potassium ion transmembrane transport	Biological Process	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005886	plasma membrane	Cellular Component	ISS	GO_REF:0000024
GO:0048471	perinuclear region of cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0008076	voltage-gated potassium channel complex	Cellular Component	ISS	GO_REF:0000024
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0015459	potassium channel regulator activity	Molecular Function	ISS	GO_REF:0000024

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.