ZBT21

Details:

UniProt Entry: Q9ULJ3
Gene: ZBTB21
Class: RING
Family: RING6
Protein length: 1066
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 1wjp

Protein Sequence ▾

>Q9ULJ3
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA SSEYFQSLFT
NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA AVQELGYSLG ISFLTNIVSK
TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI
AVKANTNKPH VPKPIEPLHN LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV
LPSKPLQDRE AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV PVYSPSIDLK
SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ VLQPHRLRSF SASQSTDREG
ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD AATTAAASSS SVTRDLSLKT EDDQKDMSRL
PAKRRFQADR RLPFKKLKVN EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT
RPNKKFKCKH CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS SSQAQQVIKR
NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV NKVAKPKEHA PLASPVENKE
VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC PYCSLRFFSP ELKQEHESKC EYKKLTCLEC
MRTFKSSFSI WRHQVEVHNQ NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT
TKDDNVFSDS SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF RLWSHFQSHM
SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE PDSPTGLSEN PTPATEKLFV
PQESDTLFYH APPLSAITFK RQFMCKLCHR TFKTAFSLWS HEQTHN

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
5	146	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
7	118	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
20	120	Domain	BTB/POZ domain	IPR000210	PF00651
30	126	Domain	BTB/POZ domain	IPR000210	SM00225
30	96	Domain	BTB/POZ domain	IPR000210	PS50097
543	584	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
546	569	Domain	Zinc finger C2H2-type	IPR013087	SM00355
546	574	Domain	Zinc finger C2H2-type	IPR013087	PS50157
548	569	Domain	Zinc finger C2H2-type	IPR013087	PS00028
575	598	Domain	Zinc finger C2H2-type	IPR013087	SM00355
577	598	Domain	Zinc finger C2H2-type	IPR013087	PS00028
668	698	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
670	692	Domain	Zinc finger C2H2-type	IPR013087	PF00096
670	697	Domain	Zinc finger C2H2-type	IPR013087	PS50157
670	692	Domain	Zinc finger C2H2-type	IPR013087	SM00355
672	692	Domain	Zinc finger C2H2-type	IPR013087	PS00028
706	747	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
722	742	Domain	Zinc finger C2H2-type	IPR013087	SM00355
746	773	Domain	ZBTB21, zinc finger domain	IPR041011	PF18450
748	768	Domain	Zinc finger C2H2-type	IPR013087	SM00355
749	771	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
772	812	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
775	798	Domain	Zinc finger C2H2-type	IPR013087	SM00355
775	803	Domain	Zinc finger C2H2-type	IPR013087	PS50157
777	798	Domain	Zinc finger C2H2-type	IPR013087	PS00028
909	959	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
909	929	Domain	Zinc finger C2H2-type	IPR013087	SM00355
909	936	Domain	Zinc finger C2H2-type	IPR013087	PS50157
937	964	Domain	Zinc finger C2H2-type	IPR013087	PS50157
937	959	Domain	Zinc finger C2H2-type	IPR013087	SM00355
939	959	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1043	1065	Domain	Zinc finger C2H2-type	IPR013087	PF00096
1043	1065	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1043	1066	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1045	1065	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:15629158
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:15629158
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:15629158
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0008327	methyl-CpG binding	Molecular Function	IDA	PMID:21029866
GO:0031208	POZ domain binding	Molecular Function	IDA	PMID:15629158
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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