AMFR

Details:

UniProt Entry: Q9UKV5

Gene: AMFR

Class: RING

Family: RING9

Protein length: 643

Database confidence: 1.0

InterPro: InterPro Entry

Mode of Action: Standalone

AlphaFold Model: Link

PDB Structures: 2ejs, 2lvn, 2lvo, 2lvp, 2lvq, 2lxh, 2lxp, 3fsh, 3h8k, 3tiw, 4g3o, 4lad

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
313	393	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
339	379	Domain	Zinc finger, RING-type	IPR001841	PF13639
341	379	Domain	Zinc finger, RING-type	IPR001841	PS50089
341	378	Domain	Zinc finger, RING-type	IPR001841	SM00184
456	497	Domain	Ubiquitin system component CUE	IPR003892	SM00546
456	498	Domain	Ubiquitin system component CUE	IPR003892	PS51140
458	497	Domain	Ubiquitin system component CUE	IPR003892	PF02845
574	600	Domain	E3 ubiquitin-protein ligase AMFR, Ube2g2-binding region	IPR040675	PF18442

GO term	Name	Ontology	Evidence	Reference
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:19675569
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:15327770
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:17310145
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007165	signal transduction	Biological Process	TAS	PMID:1649192
GO:0007611	learning or memory	Biological Process	IEA	GO_REF:0000107
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process	IBA	GO_REF:0000033
GO:0036503	ERAD pathway	Biological Process	IDA	PMID:11724934
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:15327770
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24810856
GO:0070936	protein K48-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:2000638	regulation of SREBP signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000107
GO:0030426	growth cone	Cellular Component	IEA	GO_REF:0000107
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:16275660
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:23382219
GO:0036513	Derlin-1 retrotranslocation complex	Cellular Component	IDA	PMID:17872946
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043130	ubiquitin binding	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:11724934
GO:0005515	protein binding	Molecular Function	IPI	PMID:11724934
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IMP	PMID:24424410
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:24810856
GO:0038023	signaling receptor activity	Molecular Function	IPI	PMID:1649192
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:17310145
GO:0051087	protein-folding chaperone binding	Molecular Function	IPI	PMID:21636303
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:1904288	BAT3 complex binding	Molecular Function	IPI	PMID:21636303
GO:1990381	ubiquitin-specific protease binding	Molecular Function	IPI	PMID:24424410

Enzyme–Substrate Interactions ▾


P08034	CXB1	Yes	No	No	No	—	No	E3-specific
P01009	A1AT	Yes	Yes	No	No	—	No	Cluster-specific
P04114	APOB	Yes	Yes	No	No	—	No	E3-specific
P11441	UBL4A	Yes	Yes	No	No	—	No	E3-specific
Q99574	NEUS	Yes	Yes	No	No	—	No	E3-specific
P27701	CD82	Yes	Yes	No	No	—	No	E3-specific
Q15011	HERP1	Yes	Yes	No	No	19223579	EBI-15758405	Cluster-specific

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