FBXW2

Details:

UniProt Entry: Q9UKT8
Gene: FBXW2
Class: Other E3 Components
Family: Receptor
Protein length: 454
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKT8
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK
KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC
VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYNDELDI
LVSGSADFTV KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV
IKTPEIANLA LLGFGDIFAL LFDNRYLYIM DLRTESLISR WPLPEYRKSK RGSSFLAGEA
SWLNGLDGHN DTGLVFATSM PDHSIHLVLW KEHG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	454	Family	F-box/WD repeat-containing protein 2	IPR042627	PTHR44436
52	127	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
54	101	Domain	F-box domain	IPR001810	PS50181
60	100	Domain	F-box domain	IPR001810	SM00256
60	102	Domain	F-box domain	IPR001810	PF12937
129	452	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
137	174	Repeat	WD40 repeat	IPR001680	SM00320
140	406	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
142	174	Repeat	WD40 repeat	IPR001680	PF00400
144	183	Repeat	WD40 repeat	IPR001680	PS50082
161	175	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
161	175	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
177	212	Repeat	WD40 repeat	IPR001680	SM00320
199	213	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
215	254	Repeat	WD40 repeat	IPR001680	SM00320
219	253	Repeat	WD40 repeat	IPR001680	PF00400
222	263	Repeat	WD40 repeat	IPR001680	PS50082
241	255	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
257	305	Repeat	WD40 repeat	IPR001680	SM00320
258	304	Repeat	WD40 repeat	IPR001680	PF00400
311	351	Repeat	WD40 repeat	IPR001680	SM00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006508	proteolysis	Biological Process	TAS	PMID:10531035
GO:0036211	protein modification process	Biological Process	TAS	PMID:10531035
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:11238952

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