FBX4

Details:

UniProt Entry: Q9UKT5
Gene: FBXO4
Class: Other E3 Components
Family: Receptor
Protein length: 387
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKT5
MAGSEPRSGT NSPPPPFSDW GRLEAAILSG WKTFWQSVSK ERVARTTSRE EVDEAASTLT
RLPIDVQLYI LSFLSPHDLC QLGSTNHYWN ETVRDPILWR YFLLRDLPSW SSVDWKSLPD
LEILKKPISE VTDGAFFDYM AVYRMCCPYT RRASKSSRPM YGAVTSFLHS LIIQNEPRFA
MFGPGLEELN TSLVLSLMSS EELCPTAGLP QRQIDGIGSG VNFQLNNQHK FNILILYSTT
RKERDRAREE HTSAVNKMFS RHNEGDDQQG SRYSVIPQIQ KVCEVVDGFI YVANAEAHKR
HEWQDEFSHI MAMTDPAFGS SGRPLLVLSC ISQGDVKRMP CFYLAHELHL NLLNHPWLVQ
DTEAETLTGF LNGIEWILEE VESKRAR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
16	384	Family	F-box only protein 4	IPR039588	PTHR16008
52	148	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
56	102	Domain	F-box domain	IPR001810	PS50181
60	103	Domain	F-box domain	IPR001810	PF12937
62	102	Domain	F-box domain	IPR001810	SM00256
177	381	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0002183	cytoplasmic translational initiation	Biological Process	IDA	PMID:34731628
GO:0010608	post-transcriptional regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0019725	cellular homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000107
GO:0035726	common myeloid progenitor cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0045727	positive regulation of translation	Biological Process	IDA	PMID:34731628
GO:0048147	negative regulation of fibroblast proliferation	Biological Process	IEA	GO_REF:0000107
GO:0071479	cellular response to ionizing radiation	Biological Process	IEA	GO_REF:0000107
GO:0090398	cellular senescence	Biological Process	IEA	GO_REF:0000107
GO:0140694	membraneless organelle assembly	Biological Process	ISS	PMID:35951695
GO:1900181	negative regulation of protein localization to nucleus	Biological Process	IEA	GO_REF:0000107
GO:1902916	positive regulation of protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:2000001	regulation of DNA damage checkpoint	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0010556	regulation of macromolecule biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0031647	regulation of protein stability	Biological Process	IEA	GO_REF:0000117
GO:0032212	positive regulation of telomere maintenance via telomerase	Biological Process	IMP	PMID:16275645
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16278047
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:20181953
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000120

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