FBX5

Details:

UniProt Entry: Q9UKT4
Gene: FBXO5
Class: Other E3 Components
Family: Receptor
Protein length: 447
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKT4
MSRRPCSCAL RPPRCSCSAS PSAVTAAGRP RPSDSCKEES STLSVKMKCD FNCNHVHSGL
KLVKPDDIGR LVSYTPAYLE GSCKDCIKDY ERLSCIGSPI VSPRIVQLET ESKRLHNKEN
QHVQQTLNST NEIEALETSR LYEDSGYSSF SLQSGLSEHE EGSLLEENFG DSLQSCLLQI
QSPDQYPNKN LLPVLHFEKV VCSTLKKNAK RNPKVDREML KEIIARGNFR LQNIIGRKMG
LECVDILSEL FRRGLRHVLA TILAQLSDMD LINVSKVSTT WKKILEDDKG AFQLYSKAIQ
RVTENNNKFS PHASTREYVM FRTPLASVQK SAAQTSLKKD AQTKLSNQGD QKGSTYSRHN
EFSEVAKTLK KNESLKACIR CNSPAKYDCY LQRATCKREG CGFDYCTKCL CNYHTTKDCS
DGKLLKASCK IGPLPGTKKS KKNLRRL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
258	289	Domain	F-box domain	IPR001810	PF00646
374	422	Domain	Zinc finger ZBR-type domain	IPR044064	PS51872

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001556	oocyte maturation	Biological Process	IEA	GO_REF:0000107
GO:0007057	spindle assembly involved in female meiosis I	Biological Process	IEA	GO_REF:0000107
GO:0016050	vesicle organization	Biological Process	IEA	GO_REF:0000107
GO:0040020	regulation of meiotic nuclear division	Biological Process	IEA	GO_REF:0000107
GO:0046785	microtubule polymerization	Biological Process	IEA	GO_REF:0000107
GO:0051225	spindle assembly	Biological Process	IEA	GO_REF:0000107
GO:0006275	regulation of DNA replication	Biological Process	IMP	PMID:17234884
GO:0006974	DNA damage response	Biological Process	IMP	PMID:17875940
GO:0007088	regulation of mitotic nuclear division	Biological Process	IEA	GO_REF:0000002
GO:0007346	regulation of mitotic cell cycle	Biological Process	ISS	GO_REF:0000024
GO:0008284	positive regulation of cell population proliferation	Biological Process	IMP	PMID:17234884
GO:0010948	negative regulation of cell cycle process	Biological Process	IEA	GO_REF:0000117
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	Biological Process	IMP	PMID:17485488
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032876	negative regulation of DNA endoreduplication	Biological Process	IMP	PMID:17875940
GO:0045669	positive regulation of osteoblast differentiation	Biological Process	IMP	PMID:29850565
GO:0045835	negative regulation of meiotic nuclear division	Biological Process	IBA	GO_REF:0000033
GO:0045841	negative regulation of mitotic metaphase/anaphase transition	Biological Process	IDA	PMID:11988738
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051444	negative regulation of ubiquitin-protein transferase activity	Biological Process	IDA	PMID:23708001
GO:0070169	positive regulation of biomineral tissue development	Biological Process	IMP	PMID:29850565
GO:1904667	negative regulation of ubiquitin protein ligase activity	Biological Process	IDA	PMID:11988738
GO:1905322	positive regulation of mesenchymal stem cell migration	Biological Process	IMP	PMID:29850565
GO:2000773	negative regulation of cellular senescence	Biological Process	IMP	PMID:17875940
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-174159
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0072687	meiotic spindle	Cellular Component	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:11988738
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0010997	anaphase-promoting complex binding	Molecular Function	IDA	PMID:16921029
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:15148369
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140678	molecular function inhibitor activity	Molecular Function	IDA	PMID:23708605
GO:1990948	ubiquitin ligase inhibitor activity	Molecular Function	IDA	PMID:15148369

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