FBXL2

Details:

UniProt Entry: Q9UKC9
Gene: FBXL2
Class: Other E3 Components
Family: Receptor
Protein length: 423
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKC9
MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS
TCYSLSRFCS KLKHLDLTSC VSITNSSLKG ISEGCRNLEY LNLSWCDQIT KDGIEALVRG
CRGLKALLLR GCTQLEDEAL KHIQNYCHEL VSLNLQSCSR ITDEGVVQIC RGCHRLQALC
LSGCSNLTDA SLTALGLNCP RLQILEAARC SHLTDAGFTL LARNCHELEK MDLEECILIT
DSTLIQLSIH CPKLQALSLS HCELITDDGI LHLSNSTCGH ERLRVLELDN CLLITDVALE
HLENCRGLER LELYDCQQVT RAGIKRMRAQ LPHVKVHAYF APVTPPTAVA GSGQRLCRCC
VIL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	55	Domain	F-box domain	IPR001810	PS50181
14	56	Domain	F-box domain	IPR001810	PF12937
15	55	Domain	F-box domain	IPR001810	SM00256
77	102	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
102	120	Repeat	Leucine-rich repeat	IPR001611	PF13516
103	128	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
124	192	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
129	151	Repeat	Leucine-rich repeat	IPR001611	PF13516
129	154	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
155	180	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
155	178	Repeat	Leucine-rich repeat	IPR001611	PF13516
181	206	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
193	408	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
207	230	Repeat	Leucine-rich repeat	IPR001611	PF13516
207	232	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
233	258	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
259	284	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
285	310	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
310	334	Repeat	Leucine-rich repeat	IPR001611	PF13516
311	336	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
365	391	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006508	proteolysis	Biological Process	TAS	PMID:10531035
GO:0010506	regulation of autophagy	Biological Process	IMP	PMID:23604317
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0031347	regulation of defense response	Biological Process	IEA	GO_REF:0000117
GO:0036211	protein modification process	Biological Process	TAS	PMID:10531035
GO:0044830	modulation by host of viral RNA genome replication	Biological Process	IMP	PMID:15893726
GO:0050727	regulation of inflammatory response	Biological Process	ISS	GO_REF:0000024
GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:23604317
GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	Biological Process	IDA	PMID:26037928
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:23604317
GO:0005515	protein binding	Molecular Function	IPI	PMID:15893726
GO:0005516	calmodulin binding	Molecular Function	IEA	GO_REF:0000043
GO:0019903	protein phosphatase binding	Molecular Function	IPI	PMID:23604317
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Molecular Function	IPI	PMID:23604317
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000120

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