FBW1B

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
77	116	Domain	D domain of beta-TrCP	IPR021977	SM01028
78	116	Domain	D domain of beta-TrCP	IPR021977	PF12125
112	224	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
128	167	Domain	F-box domain	IPR001810	SM00256
129	167	Domain	F-box domain	IPR001810	PS50181
131	167	Domain	F-box domain	IPR001810	PF12937
223	517	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
229	266	Repeat	WD40 repeat	IPR001680	SM00320
231	521	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
236	275	Repeat	WD40 repeat	IPR001680	PS50082
241	266	Repeat	WD40 repeat	IPR001680	PF00400
269	306	Repeat	WD40 repeat	IPR001680	SM00320
271	306	Repeat	WD40 repeat	IPR001680	PF00400
276	315	Repeat	WD40 repeat	IPR001680	PS50082
293	307	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
293	307	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
309	346	Repeat	WD40 repeat	IPR001680	SM00320
311	346	Repeat	WD40 repeat	IPR001680	PF00400
316	355	Repeat	WD40 repeat	IPR001680	PS50082
333	347	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
352	389	Repeat	WD40 repeat	IPR001680	SM00320
356	389	Repeat	WD40 repeat	IPR001680	PF00400
359	398	Repeat	WD40 repeat	IPR001680	PS50082
392	429	Repeat	WD40 repeat	IPR001680	SM00320
395	429	Repeat	WD40 repeat	IPR001680	PF00400
399	438	Repeat	WD40 repeat	IPR001680	PS50082
416	430	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
416	430	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
432	469	Repeat	WD40 repeat	IPR001680	SM00320
433	469	Repeat	WD40 repeat	IPR001680	PF00400
439	471	Repeat	WD40 repeat	IPR001680	PS50082
456	470	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
456	470	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
481	518	Repeat	WD40 repeat	IPR001680	SM00320
484	518	Repeat	WD40 repeat	IPR001680	PF00400
488	518	Repeat	WD40 repeat	IPR001680	PS50082

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000117
GO:0042753	positive regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000107
GO:0045862	positive regulation of proteolysis	Biological Process	IEA	GO_REF:0000117
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:10644755
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:25038658
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:10230407
GO:0000132	establishment of mitotic spindle orientation	Biological Process	IBA	GO_REF:0000033
GO:0006470	protein dephosphorylation	Biological Process	ISS	GO_REF:0000024
GO:0007097	nuclear migration	Biological Process	IBA	GO_REF:0000033
GO:0007281	germ cell development	Biological Process	IBA	GO_REF:0000033
GO:0008090	retrograde axonal transport	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031023	microtubule organizing center organization	Biological Process	IBA	GO_REF:0000033
GO:0047496	vesicle transport along microtubule	Biological Process	IBA	GO_REF:0000033
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0048854	brain morphogenesis	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0000776	kinetochore	Cellular Component	IBA	GO_REF:0000033
GO:0005635	nuclear envelope	Cellular Component	IBA	GO_REF:0000033
GO:0005881	cytoplasmic microtubule	Cellular Component	IBA	GO_REF:0000033
GO:0043005	neuron projection	Cellular Component	IBA	GO_REF:0000033
GO:0043025	neuronal cell body	Cellular Component	IBA	GO_REF:0000033
GO:0005813	centrosome	Cellular Component	IDA	PMID:21399614
GO:1904115	axon cytoplasm	Cellular Component	IEA	GO_REF:0000108
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0005875	microtubule associated complex	Cellular Component	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0046983	protein dimerization activity	Molecular Function	IEA	GO_REF:0000002
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:12482991
GO:0051010	microtubule plus-end binding	Molecular Function	IBA	GO_REF:0000033
GO:0070840	dynein complex binding	Molecular Function	IBA	GO_REF:0000033

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FBW1B

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾