FBXL4

Details:

UniProt Entry: Q9UKA2
Gene: FBXL4
Class: Other E3 Components
Family: Receptor
Protein length: 621
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKA2
MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE VVQYAKEVVD
FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA SLPFKRTPPN
FQSQDYVELT FEQQVYPTAV HVLETYHPGA VIRILACSAN PYSPNPPAEV RWEILWSERP
TKVNASQARQ FKPCIKQINF PTNLIRLEVN SSLLEYYTEL DAVVLHGVKD KPVLSLKTSL
IDMNDIEDDA YAEKDGCGMD SLNKKFSSAV LGEGPNNGYF DKLPYELIQL ILNHLTLPDL
CRLAQTCKLL SQHCCDPLQY IHLNLQPYWA KLDDTSLEFL QSRCTLVQWL NLSWTGNRGF
ISVAGFSRFL KVCGSELVRL ELSCSHFLNE TCLEVISEMC PNLQALNLSS CDKLPPQAFN
HIAKLCSLKR LVLYRTKVEQ TALLSILNFC SELQHLSLGS CVMIEDYDVI ASMIGAKCKK
LRTLDLWRCK NITENGIAEL ASGCPLLEEL DLGWCPTLQS STGCFTRLAH QLPNLQKLFL
TANRSVCDTD IDELACNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN
RAVLELNASF PKVFIKKSFT Q

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
265	335	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
277	332	Domain	F-box domain	IPR001810	PS50181
280	318	Domain	F-box domain	IPR001810	PF00646
285	426	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
400	425	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
427	619	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
450	475	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
478	503	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
504	524	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
532	557	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
558	583	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
584	609	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000422	autophagy of mitochondrion	Biological Process	IEA	GO_REF:0000120
GO:0000423	mitophagy	Biological Process	IMP	PMID:22505714
GO:1901525	negative regulation of mitophagy	Biological Process	IC	PMID:17636018
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:10531035
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005741	mitochondrial outer membrane	Cellular Component	IDA	PMID:36896912
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005758	mitochondrial intermembrane space	Cellular Component	IDA	PMID:23993194
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	TAS	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:38992176

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