FBXL5

Details:

UniProt Entry: Q9UKA1
Gene: FBXL5
Class: Other E3 Components
Family: Receptor
Protein length: 691
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UKA1
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI
ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT
RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS QKDTAELLRG LSLWNHAEER
QKFFKYSVDE KSDKEAEVSE HSTGITHLPP EVMLSIFSYL NPQELCRCSQ VSMKWSQLTK
TGSLWKHLYP VHWARGDWYS GPATELDTEP DDEWVKNRKD ESRAFHEWDE DADIDESEES
AEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ ILELCPNLEH
LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA LEKISRALGI LTSHQSGFLK
TSTSKITSTA WKNKDITMQS TKQYACLHDL TNKGIGEEID NEHPWTKPVS SENFTSPYVW
MLDAEDLADI EDTVEWRHRN VESLCVMETA SNFSCSTSGC FSKDIVGLRT SVCWQQHCAS
PAFAYCGHSF CCTGTALRTM SSLPESSAMC RKAARTRLPR GKDLIYFGSE KSDQETGRVL
LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTIT GAGLQDLVSA CPSLNDEYFY
YCDNINGPHA DTASGCQNLQ CGFRACCRSG E

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	160	Domain	FBXL5-like, hemerythrin-like domain	IPR045808	cd12109
8	138	Domain	Hemerythrin-like	IPR012312	PF01814
202	248	Domain	F-box domain	IPR001810	PS50181
204	289	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
205	249	Domain	F-box domain	IPR001810	PF12937
208	248	Domain	F-box domain	IPR001810	SM00256
307	459	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
355	371	Repeat	Leucine-rich repeat	IPR001611	PF13516
355	379	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
382	407	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
382	405	Repeat	Leucine-rich repeat	IPR001611	PF13516
597	622	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
598	683	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
625	650	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
626	647	Repeat	Leucine-rich repeat	IPR001611	PF13516

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006879	intracellular iron ion homeostasis	Biological Process	IEA	GO_REF:0000002
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0060586	multicellular organismal-level iron ion homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0055080	monoatomic cation homeostasis	Biological Process	IEA	GO_REF:0000117
GO:0098771	inorganic ion homeostasis	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5691108
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	NAS	PMID:10531035
GO:0005506	iron ion binding	Molecular Function	IDA	PMID:19762596
GO:0005515	protein binding	Molecular Function	IPI	PMID:17532294
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA	GO_REF:0000043
GO:0051537	2 iron, 2 sulfur cluster binding	Molecular Function	IEA	GO_REF:0000043

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.