FBX3

Details:

UniProt Entry: Q9UK99
Gene: FBXO3
Class: Other E3 Components
Family: Receptor
Protein length: 471
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UK99
MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY
WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE
GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA
AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI
IGATFTDWFT SYVKNVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV
YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY
EEMEEEEEEE EEEDEDDDSA DMDESDEDDE EERRRRVFDV PIRRRRCSRL F

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	81	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
10	56	Domain	F-box domain	IPR001810	PS50181
14	58	Domain	F-box domain	IPR001810	PF12937
16	56	Domain	F-box domain	IPR001810	SM00256
99	265	Homologous_superfamily	Knr4/Smi1-like domain superfamily	IPR037883	SSF160631
115	258	Homologous_superfamily	Knr4/Smi1-like domain superfamily	IPR037883	G3DSA:3.40.1580.10
121	251	Domain	Knr4/Smi1-like domain	IPR018958	SM00860
121	250	Domain	Knr4/Smi1-like domain	IPR018958	PF09346
275	407	Homologous_superfamily	ApaG domain superfamily	IPR036767	G3DSA:2.60.40.1470
278	408	Domain	ApaG domain	IPR007474	PS51087
280	409	Homologous_superfamily	ApaG domain superfamily	IPR036767	SSF110069
296	383	Domain	ApaG domain	IPR007474	PF04379

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006366	transcription by RNA polymerase II	Biological Process	IDA	PMID:8692841
GO:0006508	proteolysis	Biological Process	TAS	PMID:10531035
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032496	response to lipopolysaccharide	Biological Process	IDA	PMID:26037928
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:26037928
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461

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