FBX9

Details:

UniProt Entry: Q9UK97
Gene: FBXO9
Class: Other E3 Components
Family: Receptor
Protein length: 447
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UK97
MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS
SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA
MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE
LESSQIHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV
WGRSCIKLVP YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI
RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE
EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS
AFEIDKMYTP LFFARVRSYT AFSERPL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
88	123	Homologous_superfamily	MIT domain superfamily	IPR036181	SSF116846
179	439	Family	F-box only protein FBXO9/FBXO48	IPR045118	PTHR12874
185	236	Domain	F-box domain	IPR001810	PS50181
187	263	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
189	238	Domain	F-box domain	IPR001810	PF12937
252	349	Domain	F-box protein Hrt3/FBXO9, C-terminal	IPR045464	PF19270

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IDA	PMID:34480022
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34480022
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000107
GO:0045444	fat cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:15103331
GO:1904037	positive regulation of epithelial cell apoptotic process	Biological Process	IDA	PMID:34480022
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0032006	regulation of TOR signaling	Biological Process	IMP	PMID:23263282
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	NAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:22632967
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:34480022

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