FBX2

Details:

UniProt Entry: Q9UK22
Gene: FBXO2
Class: Other E3 Components
Family: Receptor
Protein length: 296
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UK22
MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA
ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR
RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ
VIDLQAEGYW EELLDTTQPA IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA
VPQDSDGGGW MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
30	296	Family	F-box only protein	IPR039752	PTHR12125
44	91	Domain	F-box domain	IPR001810	PS50181
45	140	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
48	88	Domain	F-box domain	IPR001810	PF12937
110	296	Domain	F-box associated (FBA) domain	IPR007397	SM01198
110	296	Homologous_superfamily	Galactose-binding-like domain superfamily	IPR008979	SSF49785
113	296	Domain	F-box associated (FBA) domain	IPR007397	PS51114
114	294	Domain	F-box associated (FBA) domain	IPR007397	PF04300

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0006516	glycoprotein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0031396	regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0036503	ERAD pathway	Biological Process	IEA	GO_REF:0000107
GO:0006508	proteolysis	Biological Process	TAS	PMID:10531035
GO:0008285	negative regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0036211	protein modification process	Biological Process	TAS	PMID:10531035
GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0098890	extrinsic component of postsynaptic membrane	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000120
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0043197	dendritic spine	Cellular Component	IEA	GO_REF:0000107
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0001540	amyloid-beta binding	Molecular Function	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0030246	carbohydrate binding	Molecular Function	IEA	GO_REF:0000120
GO:0031249	denatured protein binding	Molecular Function	IEA	GO_REF:0000107

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