KCND3

Details:

UniProt Entry: Q9UK17
Gene: KCND3
Class: Other E3 Components
Family: Adaptor
Protein length: 655
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UK17
MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER
YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF
YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST
LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE
YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY
TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR
AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEHMGKTTS LIESQHHHLL
HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP
GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV KVSAL

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	143	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	31	Domain	Shal-type voltage-gated potassium channels, N-terminal	IPR021645	PF11601
24	40	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
39	144	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
40	139	Domain	BTB/POZ domain	IPR000210	SM00225
42	131	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
67	80	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
81	91	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
142	158	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
147	158	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
153	303	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
159	173	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
178	192	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
184	413	Domain	Ion transport domain	IPR005821	PF00520
217	233	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
296	304	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
315	334	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
320	334	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
391	402	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
412	423	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
426	442	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
448	461	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
464	476	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
469	562	Domain	Potassium channel, voltage dependent, Kv4, C-terminal	IPR024587	PF11879
473	487	Family	Potassium channel, voltage dependent, Kv4	IPR003975	PR01497
558	570	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
582	593	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518
595	609	Family	Potassium channel, voltage dependent, Kv4.3	IPR004056	PR01518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0086009	membrane repolarization	Biological Process	IEA	GO_REF:0000117
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006936	muscle contraction	Biological Process	NAS	PMID:21349352
GO:0007268	chemical synaptic transmission	Biological Process	NAS	PMID:21349352
GO:0008016	regulation of heart contraction	Biological Process	NAS	PMID:21349352
GO:0051262	protein tetramerization	Biological Process	IDA	PMID:14980207
GO:0086013	membrane repolarization during cardiac muscle cell action potential	Biological Process	TAS	PMID:26016905
GO:0086091	regulation of heart rate by cardiac conduction	Biological Process	IMP	PMID:21349352
GO:0097623	potassium ion export across plasma membrane	Biological Process	IBA	GO_REF:0000033
GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	Biological Process	IEA	GO_REF:0000108
GO:0099625	ventricular cardiac muscle cell membrane repolarization	Biological Process	IMP	PMID:21349352
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0043025	neuronal cell body	Cellular Component	IBA	GO_REF:0000033
GO:0043197	dendritic spine	Cellular Component	IBA	GO_REF:0000033
GO:0045211	postsynaptic membrane	Cellular Component	IBA	GO_REF:0000033
GO:0098982	GABA-ergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099634	postsynaptic specialization membrane	Cellular Component	IEA	GO_REF:0000107
GO:0042383	sarcolemma	Cellular Component	IEA	GO_REF:0000044
GO:0071196	Kv4.3-KChIP1 channel complex	Cellular Component	IPI	PMID:17187064
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000120
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005250	A-type (transient outward) potassium channel activity	Molecular Function	IDA	PMID:21349352
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	Molecular Function	IMP	PMID:21349352
GO:0005515	protein binding	Molecular Function	IPI	PMID:14980207
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	Molecular Function	TAS	PMID:26016905

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