ANC2

Details:

UniProt Entry: Q9UJX6
Gene: ANAPC2
Class: Other E3 Components
Family: Scaffold
Protein length: 822
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UJX6
MAAAVVVAEG DSDSRPGQEL LVAWNTVSTG LVPPAALGLV SSRTSGAVPP KEEELRAAVE
VLRGHGLHSV LEEWFVEVLQ NDLQANISPE FWNAISQCEN SADEPQCLLL LLDAFGLLES
RLDPYLRSLE LLEKWTRLGL LMGTGAQGLR EEVHTMLRGV LFFSTPRTFQ EMIQRLYGCF
LRVYMQSKRK GEGGTDPELE GELDSRYARR RYYRLLQSPL CAGCSSDKQQ CWCRQALEQF
HQLSQVLHRL SLLERVSAEA VTTTLHQVTR ERMEDRCRGE YERSFLREFH KWIERVVGWL
GKVFLQDGPA RPASPEAGNT LRRWRCHVQR FFYRIYASLR IEELFSIVRD FPDSRPAIED
LKYCLERTDQ RQQLLVSLKA ALETRLLHPG VNTCDIITLY ISAIKALRVL DPSMVILEVA
CEPIRRYLRT REDTVRQIVA GLTGDSDGTG DLAVELSKTD PASLETGQDS EDDSGEPEDW
VPDPVDADPG KSSSKRRSSD IISLLVSIYG SKDLFINEYR SLLADRLLHQ FSFSPEREIR
NVELLKLRFG EAPMHFCEVM LKDMADSRRI NANIREEDEK RPAEEQPPFG VYAVILSSEF
WPPFKDEKLE VPEDIRAALE AYCKKYEQLK AMRTLSWKHT LGLVTMDVEL ADRTLSVAVT
PVQAVILLYF QDQASWTLEE LSKAVKMPVA LLRRRMSVWL QQGVLREEPP GTFSVIEEER
PQDRDNMVLI DSDDESDSGM ASQADQKEEE LLLFWTYIQA MLTNLESLSL DRIYNMLRMF
VVTGPALAEI DLQELQGYLQ KKVRDQQLVY SAGVYRLPKN CS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
19	819	Family	Anaphase-promoting complex subunit 2	IPR044554	PTHR45957
479	718	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
500	648	Domain	Cullin homology domain	IPR016158	SM00182
502	700	Domain	Cullin homology domain	IPR016158	PS50069
507	710	Domain	Cullin, N-terminal	IPR001373	PF00888
733	822	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
746	818	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
757	817	Domain	Anaphase-promoting complex subunit 2, C-terminal	IPR014786	SM01013
757	817	Domain	Anaphase-promoting complex subunit 2, C-terminal	IPR014786	PF08672

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000043
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010629	negative regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	NAS	PMID:15678131
GO:0031915	positive regulation of synaptic plasticity	Biological Process	ISS	GO_REF:0000024
GO:0045773	positive regulation of axon extension	Biological Process	IEA	GO_REF:0000107
GO:0050775	positive regulation of dendrite morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051445	regulation of meiotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:29033132
GO:0070979	protein K11-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0090129	positive regulation of synapse maturation	Biological Process	ISS	GO_REF:0000024
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:29033132
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-174057
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-141423
GO:0005680	anaphase-promoting complex	Cellular Component	IBA	GO_REF:0000033
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:23708001
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002

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