APC4

Details:

UniProt Entry: Q9UJX5
Gene: ANAPC4
Class: Other E3 Components
Family: Adaptor
Protein length: 808
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UJX5
MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP
NENTGKEVTC LAWRPDGKLL AFALADTKKI VLCDVEKPES LHSFSVEAPV SCMHWMEVTV
ESSVLTSFYN AEDESNLLLP KLPTLPKNYS NTSKIFSEEN SDEIIKLLGD VRLNILVLGG
SSGFIELYAY GMFKIARVTG IAGTCLALCL SSDLKSLSVV TEVSTNGASE VSYFQLETNL
LYSFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKNTTTSV
QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL
YHLSELKGMA SWKQKYEPLG LDAAGIEEAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW
LYVAMLRMTE DHVLPELNKM TQKDITFVAE FLTEHFNEAP DLYNRKGKYF NVERVGQYLK
DEDDDLVSPP NTEGNQWYDF LQNSSHLKES PLLFPYYPRK SLHFVKRRME NIIDQCLQKP
ADVIGKSMNQ AICIPLYRDT RSEDSTRRLF KFPFLWNNKT SNLHYLLFTI LEDSLYKMCI
LRRHTDISQS VSNGLIAIKF GSFTYATTEK VRRSIYSCLD AQFYDDETVT VVLKDTVGRE
GRDRLLVQLP LSLVYNSEDS AEYQFTGTYS TRLDEQCSAI PTRTMHFEKH WRLLESMKAQ
YVAGNGFRKV SCVLSSNLRH VRVFEMDIDD EWELDESSDE EEEASNKPVK IKEEVLSESE
AENQQAGAAA LAPEIVIKVE KLDPELDS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	768	Family	Anaphase-promoting complex subunit 4	IPR024789	PTHR13260
5	804	Family	Anaphase-promoting complex subunit 4, metazoa	IPR017169	PIRSF037303
12	127	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
20	220	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
27	117	Domain	Anaphase-promoting complex subunit 4, WD40 domain	IPR024977	PF12894
234	430	Domain	Anaphase-promoting complex subunit 4 long domain	IPR024790	PF12896

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030071	regulation of mitotic metaphase/anaphase transition	Biological Process	IEA	GO_REF:0000002
GO:0051445	regulation of meiotic cell cycle	Biological Process	NAS	PMID:15678131
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:29033132
GO:0070979	protein K11-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:29033132
GO:0005680	anaphase-promoting complex	Cellular Component	IEA	GO_REF:0000002
GO:0034399	nuclear periphery	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-174057
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-141423
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:6180011
GO:0005515	protein binding	Molecular Function	IPI	PMID:20360068
GO:0019903	protein phosphatase binding	Molecular Function	IPI	PMID:21241890

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