TRIM1

Details:

UniProt Entry: Q9UJV3
Gene: MID2
Class: RING
Family: RING8
Protein length: 735
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2dja, 2dmk, 7qrz

Protein Sequence ▾

>Q9UJV3
MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC FSCAHRILVS
SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSES
RRERTYRPTT AMSSERIACQ FCEQDPPRDA VKTCITCEVS YCDRCLRATH PNKKPFTSHR
LVEPVPDTHL RGITCLDHEN EKVNMYCVSD DQLICALCKL VGRHRDHQVA SLNDRFEKLK
QTLEMNLTNL VKRNSELENQ MAKLIQICQQ VEVNTAMHEA KLMEECDELV EIIQQRKQMI
AVKIKETKVM KLRKLAQQVA NCRQCLERST VLINQAEHIL KENDQARFLQ SAKNIAERVA
MATASSQVLI PDINFNDAFE NFALDFSREK KLLEGLDYLT APNPPSIREE LCTASHDTIT
VHWISDDEFS ISSYELQYTI FTGQANFISK SWCSWGLWPE IRKCKEAVSC SRLAGAPRGL
YNSVDSWMIV PNIKQNHYTV HGLQSGTRYI FIVKAINQAG SRNSEPTRLK TNSQPFKLDP
KMTHKKLKIS NDGLQMEKDE SSLKKSHTPE RFSGTGCYGA AGNIFIDSGC HYWEVVMGSS
TWYAIGIAYK SAPKNEWIGK NASSWVFSRC NSNFVVRHNN KEMLVDVPPH LKRLGVLLDY
DNNMLSFYDP ANSLHLHTFD VTFILPVCPT FTIWNKSLMI LSGLPAPDFI DYPERQECNC
RPQESPYVSG MKTCH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
17	111	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
30	80	Domain	Zinc finger, RING-type	IPR001841	PS50089
30	82	Domain	Probable E3 ubiquitin-protein ligase MID2, RING finger, HC subclass	IPR033491	cd16754
30	77	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
30	79	Domain	Zinc finger, RING-type	IPR001841	SM00184
45	54	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
134	184	Domain	B-box-type zinc finger	IPR000315	SM00336
135	187	Domain	Probable E3 ubiquitin-protein ligase MID2, B-box-type 1 zinc finger	IPR047064	cd19837
190	232	Domain	B-box-type zinc finger	IPR000315	SM00336
190	232	Domain	B-box-type zinc finger	IPR000315	PS50119
193	232	Domain	Probable E3 ubiquitin-protein ligase MID2, B-box-type 2 zinc finger	IPR047063	cd19823
194	231	Domain	B-box-type zinc finger	IPR000315	PF00643
239	365	Domain	B-box, C-terminal	IPR003649	SM00502
340	399	Domain	COS domain	IPR017903	PS51262
343	394	Domain	Midline-1, COS domain	IPR040859	PF18568
395	533	Homologous_superfamily	Fibronectin type III superfamily	IPR036116	SSF49265
401	529	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
401	531	Domain	Fibronectin type III	IPR003961	cd00063
402	522	Domain	Fibronectin type III	IPR003961	SM00060
516	709	Domain	B30.2/SPRY domain	IPR001870	PS50188
528	706	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
530	705	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
532	549	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
536	705	Domain	TRIM1, PRY/SPRY domain	IPR035752	cd13739
573	597	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
588	706	Domain	SPRY domain	IPR003877	SM00449
591	703	Domain	SPRY domain	IPR003877	PF00622
645	669	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010508	positive regulation of autophagy	Biological Process	IMP	PMID:26347139
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0035372	protein localization to microtubule	Biological Process	IBA	GO_REF:0000033
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:23077300
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IDA	PMID:18248090
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IDA	PMID:18248090
GO:1902533	positive regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005874	microtubule	Cellular Component	IEA	GO_REF:0000043
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0008017	microtubule binding	Molecular Function	IBA	GO_REF:0000033
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0042803	protein homodimerization activity	Molecular Function	IEA	GO_REF:0000117
GO:0051219	phosphoprotein binding	Molecular Function	IEA	GO_REF:0000117
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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