FBXL7

Details:

UniProt Entry: Q9UJT9
Gene: FBXL7
Class: Other E3 Components
Family: Receptor
Protein length: 491
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UJT9
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT LSTPSPALIC
PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH
SMVQIFSFLP TNQLCRCARV CRRWYNLAWD PRLWRTIRLT GETINVDRAL KVLTRRLCQD
TPNVCLMLET VTVSGCRRLT DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL
EHLDVSGCSK VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES RLRYLSIAHC
GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN CTKLKSLDIG KCPLVSDTGL
ECLALNCFNL KRLSLKSCES ITGQGLQIVA ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR
CVIEHTNPAF F

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
107	157	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
111	157	Domain	F-box domain	IPR001810	PS50181
114	159	Domain	F-box domain	IPR001810	PF12937
117	157	Domain	F-box domain	IPR001810	SM00256
156	265	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
185	210	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
211	236	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
237	262	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
271	296	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
273	489	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
296	319	Repeat	Leucine-rich repeat	IPR001611	PF13516
297	322	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
323	348	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
349	374	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
351	369	Repeat	Leucine-rich repeat	IPR001611	PF13516
374	398	Repeat	Leucine-rich repeat	IPR001611	PF13516
375	400	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
400	424	Repeat	Leucine-rich repeat	IPR001611	PF13516
401	426	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
427	452	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
427	446	Repeat	Leucine-rich repeat	IPR001611	PF13516
453	477	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	ISS	GO_REF:0000024
GO:0000278	mitotic cell cycle	Biological Process	ISS	GO_REF:0000024
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS	PMID:10531035
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8853496
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:25778398

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