KLH21

Details:

UniProt Entry: Q9UJP4
Gene: KLHL21
Class: Other E3 Components
Family: Adaptor
Protein length: 597
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UJP4
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH RAVLAAASPY
FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA VSGDNAEPLL RAADLLQFPA
VKEACGAFLQ QQLDLANCLD MQDFAEAFSC SGLASAAQRF ILRHVGELGA EQLERLPLAR
LLRYLRDDGL CVPKEEAAYQ LALRWVRADP PRRAAHWPQL LEAVRLPFVR RFYLLAHVEA
EPLVARCPPC LRLLREARDF QAARYDRHDR GPCPRMRPRP STGLAEILVL VGGCDQDCDE
LVTVDCYNPQ TGQWRYLAEF PDHLGGGYSI VALGNDIYVT GGSDGSRLYD CVWRYNSSVN
EWAEVAPMLK AREYHSSSVL DGLLYVVAAD STERYDHTTD SWEALQPMTY PMDNCSTTAC
RGRLYAIGSL AGKETMVMQC YDPDTDLWSL VDCGQLPPWS FAPKTATLNG LMYFVRDDSA
EVDVYNPTRN EWDKIPSMNQ VHVGGSLAVL GGKLYVSGGY DNTFELSDVV EAYDPETRAW
SVVGRLPEPT FWHGSVSIFR QFMPQTFSGG RGFELDSGSD DMDPGRPRPP RDPDELH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	563	Family	BTB-kelch protein	IPR017096	PIRSF037037
8	134	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
12	131	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	138	Domain	Kelch-like protein 21, BTB/POZ domain	IPR030577	cd18250
25	132	Domain	BTB/POZ domain	IPR000210	PF00651
35	133	Domain	BTB/POZ domain	IPR000210	SM00225
35	103	Domain	BTB/POZ domain	IPR000210	PS50097
133	232	Domain	Kelch-like protein 21, BACK domain	IPR047069	cd18460
138	239	Domain	BTB/Kelch-associated	IPR011705	SM00875
138	239	Domain	BTB/Kelch-associated	IPR011705	PF07707
272	563	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
287	556	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
287	334	Repeat	Kelch repeat type 1	IPR006652	SM00612
288	320	Repeat	Kelch repeat type 1	IPR006652	PF01344
327	368	Repeat	Kelch repeat type 1	IPR006652	PF01344
336	382	Repeat	Kelch repeat type 1	IPR006652	SM00612
383	422	Repeat	Kelch repeat type 1	IPR006652	SM00612
471	512	Repeat	Kelch repeat type 1	IPR006652	SM00612
513	560	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032465	regulation of cytokinesis	Biological Process	IMP	PMID:19995937
GO:0035853	chromosome passenger complex localization to spindle midzone	Biological Process	IMP	PMID:19995937
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005827	polar microtubule	Cellular Component	IDA	PMID:19995937
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19995937
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0097602	cullin family protein binding	Molecular Function	IPI	PMID:14528312
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.