RABX5

Details:

UniProt Entry: Q9UJ41
Gene: RABGEF1
Class: RING
Family: RING1
Protein length: 491
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 1txu, 2c7m, 2c7n, 2ot3, 4n3x, 4n3y, 4n3z, 4q9u

Protein Sequence ▾

>Q9UJ41
MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA
KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE
CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK
RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN
AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC
CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL
NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL
PPPLQPQVYA G

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	472	Family	Vacuolar protein sorting-associated protein 9-like	IPR045046	PTHR23101
13	47	Domain	Zinc finger, A20-type	IPR002653	PS51036
16	40	Domain	Zinc finger, A20-type	IPR002653	SM00259
17	40	Domain	Zinc finger, A20-type	IPR002653	PF01754
135	386	Homologous_superfamily	VPS9 domain superfamily	IPR037191	SSF109993
158	220	Domain	RABX5, catalytic core helical domain	IPR041545	PF18151
228	397	Homologous_superfamily	VPS9 domain superfamily	IPR037191	G3DSA:1.20.1050.80
232	375	Domain	VPS9 domain	IPR003123	PS51205
262	383	Domain	VPS9 domain	IPR003123	SM00167
270	370	Domain	VPS9 domain	IPR003123	PF02204

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000002
GO:0006897	endocytosis	Biological Process	IEA	GO_REF:0000043
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0006898	receptor-mediated endocytosis	Biological Process	IEA	GO_REF:0000107
GO:0007265	Ras protein signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0038109	Kit signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0043303	mast cell degranulation	Biological Process	IEA	GO_REF:0000107
GO:0051649	establishment of localization in cell	Biological Process	IEA	GO_REF:0000107
GO:0097531	mast cell migration	Biological Process	IEA	GO_REF:0000107
GO:0002686	negative regulation of leukocyte migration	Biological Process	IEA	GO_REF:0000107
GO:0032715	negative regulation of interleukin-6 production	Biological Process	IEA	GO_REF:0000107
GO:0032764	negative regulation of mast cell cytokine production	Biological Process	IEA	GO_REF:0000107
GO:0033004	negative regulation of mast cell activation	Biological Process	IEA	GO_REF:0000107
GO:0043305	negative regulation of mast cell degranulation	Biological Process	IEA	GO_REF:0000107
GO:0046580	negative regulation of Ras protein signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	IEA	GO_REF:0000107
GO:0050728	negative regulation of inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1900235	negative regulation of Kit signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0006612	protein targeting to membrane	Biological Process	IMP	PMID:23382462
GO:0016197	endosomal transport	Biological Process	IDA	PMID:11452015
GO:0098935	dendritic transport	Biological Process	IEA	GO_REF:0000107
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0031982	vesicle	Cellular Component	IEA	GO_REF:0000117
GO:0055037	recycling endosome	Cellular Component	IEA	GO_REF:0000044
GO:0030139	endocytic vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0031901	early endosome membrane	Cellular Component	IDA	PMID:11452015
GO:0098830	presynaptic endosome	Cellular Component	IEA	GO_REF:0000107
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000108
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0031267	small GTPase binding	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾

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