KCNG1

Details:

UniProt Entry: Q9UIX4
Gene: KCNG1
Class: Other E3 Components
Family: Adaptor
Protein length: 513
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9UIX4
MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS
LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI
TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
41	176	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
63	177	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
63	172	Domain	BTB/POZ domain	IPR000210	SM00225
65	164	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
99	111	Family	Potassium channel, voltage dependent, Kv6	IPR003969	PR01492
114	124	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
134	150	Family	Potassium channel, voltage dependent, Kv6	IPR003969	PR01492
153	168	Family	Potassium channel, voltage dependent, Kv6	IPR003969	PR01492
203	359	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
206	218	Family	Potassium channel, voltage dependent, Kv6	IPR003969	PR01492
227	467	Domain	Ion transport domain	IPR005821	PF00520
352	360	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
376	390	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
448	459	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
464	478	Family	Potassium channel, voltage dependent, Kv6	IPR003969	PR01492

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000043
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000002
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000108
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0043266	regulation of potassium ion transport	Biological Process	IEA	GO_REF:0000107
GO:1901379	regulation of potassium ion transmembrane transport	Biological Process	ISS	GO_REF:0000024
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0015459	potassium channel regulator activity	Molecular Function	IEA	GO_REF:0000117

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.