HERC5

Details:

UniProt Entry: Q9UII4
Gene: HERC5
Class: HECT
Family: HECT1
Protein length: 1024
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9UII4
MERRSRRKSR RNGRSTAGKA AATQPAKSPG AQLWLFPSAA GLHRALLRRV EVTRQLCCSP
GRLAVLERGG AGVQVHQLLA GSGGARTPKC IKLGKNMKIH SVDQGAEHML ILSSDGKPFE
YDNYSMKHLR FESILQEKKI IQITCGDYHS LALSKGGELF AWGQNLHGQL GVGRKFPSTT
TPQIVEHLAG VPLAQISAGE AHSMALSMSG NIYSWGKNEC GQLGLGHTES KDDPSLIEGL
DNQKVEFVAC GGSHSALLTQ DGLLFTFGAG KHGQLGHNST QNELRPCLVA ELVGYRVTQI
ACGRWHTLAY VSDLGKVFSF GSGKDGQLGN GGTRDQLMPL PVKVSSSEEL KLESHTSEKE
LIMIAGGNQS ILLWIKKENS YVNLKRTIPT LNEGTVKRWI ADVETKRWQS TKREIQEIFS
SPACLTGSFL RKRRTTEMMP VYLDLNKARN IFKELTQKDW ITNMITTCLK DNLLKRLPFH
SPPQEALEIF FLLPECPMMH ISNNWESLVV PFAKVVCKMS DQSSLVLEEY WATLQESTFS
KLVQMFKTAV ICQLDYWDES AEENGNVQAL LEMLKKLHRV NQVKCQLPES IFQVDELLHR
LNFFVEVCRR YLWKMTVDAS ENVQCCVIFS HFPFIFNNLS KIKLLHTDTL LKIESKKHKA
YLRSAAIEEE RESEFALRPT FDLTVRRNHL IEDVLNQLSQ FENEDLRKEL WVSFSGEIGY
DLGGVKKEFF YCLFAEMIQP EYGMFMYPEG ASCMWFPVKP KFEKKRYFFF GVLCGLSLFN
CNVANLPFPL ALFKKLLDQM PSLEDLKELS PDLGKNLQTL LDDEGDNFEE VFYIHFNVHW
DRNDTNLIPN GSSITVNQTN KRDYVSKYIN YIFNDSVKAV YEEFRRGFYK MCDEDIIKLF
HPEELKDVIV GNTDYDWKTF EKNARYEPGY NSSHPTIVMF WKAFHKLTLE EKKKFLVFLT
GTDRLQMKDL NNMKITFCCP ESWNERDPIR ALTCFSVLFL PKYSTMETVE EALQEAINNN
RGFG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
53	397	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
83	351	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
140	153	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
143	153	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
157	206	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
157	209	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
159	175	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
209	258	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
210	261	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
210	226	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
248	264	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
248	258	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
261	309	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
262	313	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
264	278	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
315	368	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
315	377	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
676	1020	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
681	1024	Domain	HECT domain	IPR000569	cd00078
700	1024	Domain	HECT domain	IPR000569	SM00119
702	1024	Domain	HECT domain	IPR000569	PS50237
733	1024	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:15331633
GO:0032020	ISG15-protein conjugation	Biological Process	IDA	PMID:16407192
GO:0045087	innate immune response	Biological Process	IDA	PMID:28724761
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	Biological Process	TAS	PMID:10581175
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0039585	PKR/eIFalpha signaling	Biological Process	TAS	Reactome:R-HSA-9833482
GO:0050688	regulation of defense response to virus	Biological Process	IDA	PMID:20308324
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1169394
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:20133869
GO:0042296	ISG15 transferase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


P22392	NDKB	Yes	Yes	No	No	—	No	E3-specific
Q13363	CTBP1	Yes	No	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P22392	NDKB	Yes	Yes	No	No	—	No	E3-specific
Q13363	CTBP1	Yes	No	No	No	—	No	E3-specific